CORE--NUCLEAR CONTROL OF CELL GROWTH AND DIFFERENTIATION

核心--细胞生长和分化的核控制

• 批准号: 6189646
• 负责人: Barbara J Graves
• 金额: --
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-05 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6189646
• 关键词: biomedical facility; cell differentiation; cell growth regulation; gene expression; genetic regulation; regulatory gene

The Program in the Nuclear Control of Cell Growth and Differentiation emphasizes research on the basic biological regulatory processes that maintain genome stability and regulate gene expression. The faithful inheritance and readout genetic information involves many regulated processes including DNA replication and repair, RNA synthesis and processing and protein synthesis. Members of this program investigate the molecular basis of these processes by a combination of approaches spanning from traditional genetics to biophysical techniques. Genetic analyses in model systems have led to discoveries of new genes and their functions. On the other hand, biochemical and biophysical studies of regulatory proteins are ongoing in many arenas. Experimental systems include bacteria, yeast, Drosophila, C. elegans, mouse, zebrafish and humans as well as bacteriophages and animal viruses. These fundamental processes employ the same molecular mechanisms that are dysregulated in cancer. Many research projects are focused directly on cancer biology while others are exploiting model systems to discover the molecules that execute basic biological regulatory events.

细胞生长和分化的核控制程序的计划强调了维持基因组稳定性并调节基因表达的基本生物调节过程的研究。忠实的遗传和读数遗传信息涉及许多调控过程，包括DNA复制和修复，RNA合成和加工以及蛋白质合成。该计划的成员通过从传统遗传学到生物物理技术的方法组合来研究这些过程的分子基础。模型系统中的遗传分析导致了新基因及其功能的发现。另一方面，在许多领域，调节蛋白的生化和生物物理研究正在进行中。实验系统包括细菌，酵母，果蝇，秀丽隐杆线虫，小鼠，斑马鱼和人类以及噬菌体和动物病毒。这些基本过程采用了与癌症失调相同的分子机制。许多研究项目直接关注癌症生物学，而其他研究项目则利用模型系统来发现执行基本生物学调节事件的分子。