Transcriptional Regulation during Cell Growth

细胞生长过程中的转录调控

基本信息

批准号：
6809241
负责人：
Barbara J Graves
金额：
$ 1.4万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2005-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6809241
关键词：
cell cycle cell differentiation genetic transcription meeting /conference /symposium travel

项目摘要

DESCRIPTION (provided by applicant): This application requests partial funding for a FASEB conference on "Transcriptional Regulation during Cell Growth, Differentiation, and Development", at Saxton River, Vermont from August 14 to 18, 2004. The regulation of gene expression at the level of transcription is critical for a wide variety of cellular processes, including cell growth, division, signaling, and death. Transcriptional regulation also plays an important role in the differentiation and the development of multicellular organisms, including the formation of specific cell types, tissues, and organs. The purpose of the conference is to bring together biochemists and molecular biologists studying fundamental mechanisms of transcription with cell and developmental biologists studying biological processes that are dependent on transcriptional regulation. The meeting blends model systems approaches (frog, fly, worm, mouse, and yeast) with rigorous biochemical approaches. Sessions will communicate recent advances in understanding transcriptional initiation and elongation, activation and repression, chromatin and chromosome structure, epigenetics, cell cycle control, and cell signaling and development. The conference will explore the role of transcriptional regulation in normal cell growth, differentiation, and development, as well as how alterations in transcription cause birth defects, cancer, and disease in humans. The conference goes beyond the mechanistic aspects of transcription to emphasize how cells use transcription during growth and differentiation, as well as development of multicellular organisms. The recent availability of whole genome sequences and the avalanche of microarray studies have added a new, global dimension to these questions. This meeting is unique within both the transcription field and the developmental biology field, and thus provides a unparalleled opportunity for interactions across disciplines. This conference will provide an up-to-date overview of one of the most fundamental and rapidly moving fields in biology, as well as the generation of new directions for future research.

描述（由申请人提供）：本申请要求在2004年8月14日至184日在佛蒙特州的Saxton River举行的关于“细胞生长，分化和开发过程中的转录调节”会议的部分资金。在2004年8月14日至18日。转录水平上基因表达的调节对于各种细胞生长，包括细胞生长，分区，信号，信号，和死亡至关重要。转录调节在多细胞生物的分化和发展中也起着重要作用，包括特定细胞类型，组织和器官的形成。会议的目的是将生物化学家和分子生物学家汇总，研究转录的基本机制，并研究细胞和发育生物学家，研究依赖转录调控的生物学过程。这次会议将模型系统方法（青蛙，苍蝇，蠕虫，老鼠和酵母）与严格的生化方法融为一体。会议将传达在理解转录起始和伸长，激活和抑制，染色质和染色体结构，表观遗传学，细胞周期控制以及细胞信号传导和发育方面的最新进展。该会议将探讨转录调节在正常细胞生长，分化和发育中的作用，以及转录变化如何引起人类的先天缺陷，癌症和疾病。该会议超出了转录的机械方面，以强调细胞在生长和分化过程中如何使用转录以及多细胞生物的发展。整个基因组序列和微阵列研究的雪崩的最新可用性为这些问题增加了一个新的全球维度。这次会议在转录领域和发展生物学领域都是独一无二的，因此为跨学科的互动提供了无与伦比的机会。这次会议将为生物学中最基本和快速移动的领域之一以及未来研究的新方向提供最新的概述。