13 WEEK ORAL TOXICITY OF BLACK TEA POLYPHENOLS

亚慢性、90天、重复给药、口服研究， 将在大鼠和狗中评价多酚的复杂混合物。 终点将包括食物和水消耗量、体重， 临床观察、心脏和眼科评估、临床 生化和血液学、血浆检测试剂水平、尿分析，以及 解剖学和组织病理学。 器官毒性和剂量 与最大耐受剂量和无不良反应相关 水平将得到确认。

Subchronic, 90-day, repeat-dose, oral studies of a characterized, complex mixture of polyphenols will be evaluated in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Organ toxicities and dosages associated with a maximum tolerated dose and a no adverse effect level will be identified.