13 WEEK ORAL TOXICITY OF BLACK TEA POLYPHENOLS

红茶多酚 13 周口服毒性

• 批准号: 2879215
• 负责人: MALCOLM BLAIR
• 金额: $ 27.93万
• 依托单位: SPRINGBORN LIFE SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2879215
• 关键词: blood tests; body weight; cancer prevention; carcinogenesis inhibitor; chemoprevention; clinical chemistry; dogs; dosage; drug adverse effect; drug screening /evaluation; eating; hematology; histopathology; laboratory rat; medicinal plants; phenols; plant extracts; polymers; tea; urinalysis; water drinking behavior

Subchronic, 90-day, repeat-dose, oral studies of a characterized, complex mixture of polyphenols will be evaluated in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Organ toxicities and dosages associated with a maximum tolerated dose and a no adverse effect level will be identified.

亚慢性，90天，重复给药，口服研究， 多酚的复杂混合物将在大鼠和狗身上进行评估。 终点将包括食物和水的消耗量、体重、 临床观察、心眼评估、临床 化学和血液学，血浆检测试剂水平，尿液分析，和 解剖和组织病理学。器官毒性和剂量 与最大耐受量和无不良反应有关 级别将被确定。