Linking insufficient sleep with body weight in Black emerging adults.

将睡眠不足​​与黑人新生成年人的体重联系起来。

• 批准号: 10665139
• 负责人: Jessica Nicole McNeil
• 金额: $ 62.52万
• 依托单位: UNIVERSITY OF NORTH CAROLINA GREENSBORO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665139
• 关键词: Adolescence; Adult; Age; Biological; Black race; Body Weight; Communities; Cross-Sectional Studies; Data Collection; Desire for food; Disadvantaged; Discrimination; Disparity; Economics; Energy Intake; Energy Metabolism; Environment; Fatty acid glycerol esters; Feeling; Food; Health behavior; Home; Hydration status; Hydrocortisone; Individual; Intervention; Knowledge; Laboratories; Link; Measures; Mediating; Methods; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; Neighborhoods; Obesity; Participant; Pathway interactions; Patient Recruitments; Patient Self-Report; Polysomnography; Population; Prevalence; Prospective Studies; Public Health; Race; Research Activity; Research Personnel; Research Support; Rewards; Risk; Role; Sample Size; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Slow-Wave Sleep; Socialization; Societies; Stress; Surveys; Technology; Weight; Weight Gain; Work; actigraphy; biological systems; coping; diaries; disparity reduction; emerging adult; emerging adulthood; energy balance; experience; follow-up; high risk; insight; interest; lifestyle intervention; obesity risk; peer; poor sleep; prospective; racial identity; racial population; racism; response; sleep behavior; sleep onset; sleep quality; social; vigilance; waist circumference

PROJECT ABSTRACT Compared to peers in other racial groups, Black emerging adults (18-28 years old) have the highest risks of short sleep duration and obesity. This increased risk may be partly explained by greater stress levels resulting from race-related stress (feelings of discrimination and heightened vigilance) and living in more disadvantaged home and neighborhood environments. Insufficient sleep (longer sleep-onset latency, shorter sleep duration, poorer sleep quality and efficiency, less slow-wave sleep, and more severe sleep-disordered breathing) may also impact obesity risk via several weight-related mechanisms. These include (a) energy balance (difference between energy intake and energy expenditure), (b) appetite and food reward, (c) cortisol awakening response and diurnal cortisol profiles, and (d) hydration status. We will prospectively assess effects of insufficient sleep, race-related stress and living in more disadvantaged home and neighborhood environments on weight-related mechanisms and obesity markers (body weight, waist circumference and fat mass) in 150 Black emerging adults. Participants will complete 3, 7-day data collection bursts over 1 year (baseline, 6-month, and 12-month follow- up). Insufficient sleep variables will be measured with 3 methods: sleep diary, actigraphy and polysomnography. Self-report and objective methods will be used to assess weight-related mechanisms. Race-related stress will be self-reported. Home and neighborhood environments (via the Windshield Survey) will be observer-assessed. Aim 1 will examine prospective effects of insufficient sleep on weight-related mechanisms and obesity markers. Aim 2 will examine prospective effects of race-related stress and living in more disadvantaged home and neighborhood environments on insufficient sleep variables, weight-related mechanisms, and obesity markers. Aim 3 will assess the mediating role of sleep on associations among race-related stress, living in more disadvantaged home and neighborhood environments, weight-related mechanisms, and obesity markers. Our overarching hypothesis is that higher amounts of insufficient sleep and race-related stress and living in more disadvantaged home and neighborhood environments will be associated with (a) greatest energy intake and positive energy balance, (b) greatest appetite and food reward, (c) flattest diurnal cortisol profiles and lowest cortisol awakening response, (d) lowest hydration, and (e) greatest weight gain, waist circumference and fat mass at 1 year. This proposal, led by an Early-Stage Investigator and submitted in response to PAR-20-164 (Mechanisms and Consequences of Sleep Disparities in the U.S.), could have significant public health implications by identifying how and why insufficient sleep increases obesity risk in Black emerging adults.

项目摘要 与其他种族的同龄人相比，黑人新兴成年人(18-28岁)患上糖尿病的风险最高 睡眠时间短和肥胖。风险增加的部分原因可能是由此产生的更大的压力水平 来自种族相关的压力(受歧视的感觉和高度的警觉)和生活在更不利的环境中 家庭和邻里环境。睡眠不足(入睡潜伏期较长，睡眠持续时间较短， 较差的睡眠质量和效率，较少的慢波睡眠，以及更严重的睡眠障碍呼吸)可能 还通过几种与体重相关的机制影响肥胖风险。其中包括：(A)能量平衡(差额 能量摄入和能量消耗之间)，(B)食欲和食物奖励，(C)皮质醇唤醒反应 和昼夜皮质醇曲线，以及(D)水合状态。我们将前瞻性地评估睡眠不足的影响， 与种族相关的压力和生活在更不利的家庭和邻里环境中的体重相关 150名黑人新兴成年人的肥胖机制和肥胖标记物(体重、腰围和脂肪质量)。 参与者将在一年内完成3到7天的数据收集突发事件(基准、6个月和12个月的跟踪- 向上)。不足的睡眠变量将用3种方法测量：睡眠日记、活动记录仪和多导睡眠记录仪。 将使用自我报告和客观方法来评估与权重有关的机制。种族相关的压力会 自我报告。家庭和邻里环境(通过挡风玻璃调查)将由观察者进行评估。 目标1将研究睡眠不足对体重相关机制和肥胖标记物的预期影响。 目标2将研究与种族相关的压力和生活在更不利的家庭和 邻里环境对睡眠变量、体重相关机制和肥胖标记物的影响。 目标3将评估睡眠在种族相关压力、生活在更多 不利的家庭和邻里环境、与体重相关的机制和肥胖标记物。我们的 最重要的假设是睡眠不足的人越多，种族相关的压力越大，生活在 不利的家庭和邻里环境将与(A)最大的能量摄入量和 正能量平衡，(B)最大的食欲和食物奖励，(C)最平坦的昼夜皮质醇分布和最低 皮质醇唤醒反应，(D)最低的水分，和(E)最大的体重增加，腰围和脂肪 质量在1岁时。该提案由一名早期调查人员牵头，并根据PAR-20-164提交 (美国睡眠不平等的机制和后果)，可能会对公共卫生产生重大影响 通过确定睡眠不足如何以及为什么会增加黑人新兴成年人的肥胖风险来揭示这一问题。