PHYSIOLOGY AND PLASTICITY OF VISUAL CORTICAL SYNAPSES

描述（改编自申请人的摘要）： 这个项目是为了了解兴奋性突触的特性 是视觉皮层局部回路信息处理的基础。我们有 已建立的记录个体间突触相互作用的技术 皮质神经元建议从特定类型进行双重记录 突触连接的神经元。我们应该研究兴奋性联系， 锥体神经元以及锥体神经元与锥体神经元之间的兴奋性连接 抑制性神经元我们的实验结果将使我们了解 局部皮层兴奋性相互作用的机制和功能 电路.具体而言，本提案的目的是：1.什么是突触 在长时间激活过程中单一兴奋性连接的动力学？2.什么 是单个突触前锥体细胞轴突的活动对神经元的影响。 突触后靶细胞的峰值

DESCRIPTION (Adapted From The Applicant's Abstract): The long-term objective of this project is to understand how the properties of excitatory synapses underlie information processing in local circuits in the visual cortex. We have established techniques for recording synaptic interactions among individual cortical neurons. It is proposed to perform dual recording from specific types of synaptically connected neurons. We should study excitatory connections among pyramidal neurons and excitatory connections between pyramidal neurons and inhibitory neurons. The results of our experiments will allow us to understand both the mechanism and function of excitatory interactions in local cortical circuits. Specifically, the aims of this proposal are: 1. What are the synaptic dynamics of unitary excitatory connections during prolonged activation? 2. What is the impact of activity of a single presynaptic pyramidal cell axon on the spiking of its postsynaptic target cell?