BINDING PROPERTIES OF HUMAN CENTRIN 2 AND CALBINDIN D28K

人类 Centrin 2 和 Calbindin D28K 的结合特性

• 批准号: 7953935
• 负责人: Rajiv Kumar
• 金额: $ 1.4万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953935
• 关键词: Affinity; Binding; Binding Proteins; Calcium Binding; Computer Retrieval of Information on Scientific Projects Database; Family member; Funding; Grant; Institution; Ligands; Mass Spectrum Analysis; Property; Proteins; Research; Research Personnel; Resources; Source; Titrations; United States National Institutes of Health; biomedical resource; calbindin-D28K; human centrin-2 protein; stoichiometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human centrin 2 (20 kDa) and calbindin D28K (30 kDa) are members of the family of Ca2+-binding proteins. We use PLIMSTEX, the study of Protein Ligand Interactions by Mass Spectrometry, Titration, and H/D Exchange, to explore the calcium binding properties of these proteins. This strategy can show the conformational change upon binding calcium, the affinity constants, and also the binding stoichiometry.

这个子项目是众多研究子项目之一