STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS
STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS
批准号:
2888426
负责人:
JONATHAN C HORTON
金额:
$35.58万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-07-01 至 2003-06-30
关键词:
Macaca mulatta Saimiri age difference amblyopia autoradiography binocular vision brain mapping electrophysiology eye coordination disorder functional magnetic resonance imaging histochemistry /cytochemistry human tissue microinjections neural plasticity neuroanatomy pathologic process structural biology visual cortex visual deprivation visual fields
中文摘要
这个项目的主要目标是发现生理学和
人类和猴子弱视的解剖学相关性。这将是
延续S关于眼球结构的前一次授权
动物和人类的优势柱(ODC)。有5个新的特定
他将研究的目标是:(1)斜视对
眼优势柱的周期性,(2)可能的破坏
V1中第4C层到第3层的固有连接,(3)更改
在人类弱视的ODC的完整模式中,组织
V2中的CO条纹,以及其他条纹外视觉的组织
区域,(4)斜视的皮质视觉抑制中心和
(5)猕猴背侧V2前方视觉区域的身份
包含一种独特的CO模式。总之,这些新的实验将
通过研究ODC之外的机制来扩展以前的工作
这可能是弱视视力不佳的原因。
英文摘要
The primary goal of this project is to uncover physiological and
anatomical correlates of amblyopia in both humans and monkeys. This will
continue the P.I.'s previous grant concerning the structure of ocular
dominance columns (ODC) in animals and humans. There are 5 new specific
aims that he will investigate: (1) The effect of strabismus on
periodicity of ocular dominance columns, (2) Possible disruption of
intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations
in human amblyopes of the complete pattern of ODC's, the organization
of CO stripes in V2, and the organization of other extrastriate visual
areas, (4) the cortical locus of visual suppression in strabismus and
(5) the identity of a visual area anterior to macaque dorsal V2 that
contains a unique CO pattern. Together, these new experiments will
extend the previous work by investigating mechanisms beyond the ODC's
that might be responsible for the poor vision in amblyopia.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
BINOCULAR FUNCTION IN STRABISMUS
-
批准号:10547826
-
项目类别:
-
资助金额:$65.12万
-
财政年份:2019
-
负责人:JONATHAN C HORTON
-
依托单位:
BINOCULAR FUNCTION IN STRABISMUS
-
批准号:10331734
-
项目类别:
-
资助金额:$64.46万
-
财政年份:2019
-
负责人:JONATHAN C HORTON
-
依托单位:
CORE--COMPUTER /IT SUPPORT MODULE
-
批准号:6720345
-
项目类别:
-
资助金额:$14.13万
-
财政年份:2003
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA IN MONKEYS & HUMANS
-
批准号:6277969
-
项目类别:
-
资助金额:$5.21万
-
财政年份:1998
-
负责人:JONATHAN C HORTON
-
依托单位:
Computing/IT Core
-
批准号:10203973
-
项目类别:
-
资助金额:$20.39万
-
财政年份:1997
-
负责人:JONATHAN C HORTON
-
依托单位:
Computing/IT Core
-
批准号:10426214
-
项目类别:
-
资助金额:$20.39万
-
财政年份:1997
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA IN MONKEYS & HUMANS
-
批准号:6247836
-
项目类别:
-
资助金额:$2.28万
-
财政年份:1997
-
负责人:JONATHAN C HORTON
-
依托单位:
Computing/IT Core
-
批准号:10665569
-
项目类别:
-
资助金额:$20.39万
-
财政年份:1997
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS
-
批准号:6384375
-
项目类别:
-
资助金额:$38.76万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
Structural Basis of Amblyopia and Strabismus
-
批准号:6792747
-
项目类别:
-
资助金额:$52.59万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
Structural Basis of Amblyopia and Strabismus
-
批准号:7650334
-
项目类别:
-
资助金额:$38.63万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA
-
批准号:2163938
-
项目类别:
-
资助金额:$18.84万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA
-
批准号:2163939
-
项目类别:
-
资助金额:$19.86万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA
-
批准号:3267413
-
项目类别:
-
资助金额:$24.02万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS
-
批准号:6179978
-
项目类别:
-
资助金额:$31.1万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
Structural Basis of Amblyopia and Strabismus
-
批准号:7236068
-
项目类别:
-
资助金额:$50.9万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
Structural Basis of Amblyopia and Strabismus
-
批准号:7633548
-
项目类别:
-
资助金额:$36.91万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA
-
批准号:2444358
-
项目类别:
-
资助金额:$16.55万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
Structural Basis of Amblyopia and Strabismus
-
批准号:8990477
-
项目类别:
-
资助金额:$59.01万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
STRUCTURAL BASIS OF AMBLYOPIA
-
批准号:2163937
-
项目类别:
-
资助金额:$18.1万
-
财政年份:1993
-
负责人:JONATHAN C HORTON
-
依托单位:
海外基金