STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS

这个项目的主要目标是发现生理学和 人类和猴子弱视的解剖学相关性。这将是 延续S关于眼球结构的前一次授权 动物和人类的优势柱(ODC)。有5个新的特定 他将研究的目标是：(1)斜视对 眼优势柱的周期性，(2)可能的破坏 V1中第4C层到第3层的固有连接，(3)更改 在人类弱视的ODC的完整模式中，组织 V2中的CO条纹，以及其他条纹外视觉的组织 区域，(4)斜视的皮质视觉抑制中心和 (5)猕猴背侧V2前方视觉区域的身份 包含一种独特的CO模式。总之，这些新的实验将 通过研究ODC之外的机制来扩展以前的工作 这可能是弱视视力不佳的原因。

The primary goal of this project is to uncover physiological and anatomical correlates of amblyopia in both humans and monkeys. This will continue the P.I.'s previous grant concerning the structure of ocular dominance columns (ODC) in animals and humans. There are 5 new specific aims that he will investigate: (1) The effect of strabismus on periodicity of ocular dominance columns, (2) Possible disruption of intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations in human amblyopes of the complete pattern of ODC's, the organization of CO stripes in V2, and the organization of other extrastriate visual areas, (4) the cortical locus of visual suppression in strabismus and (5) the identity of a visual area anterior to macaque dorsal V2 that contains a unique CO pattern. Together, these new experiments will extend the previous work by investigating mechanisms beyond the ODC's that might be responsible for the poor vision in amblyopia.