STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS

弱视和斜视的结构基础

• 批准号: 6384375
• 负责人: JONATHAN C HORTON
• 金额: $ 38.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6384375
• 关键词: Macaca mulatta; Saimiri; age difference; amblyopia; autoradiography; binocular vision; brain mapping; electrophysiology; eye coordination disorder; functional magnetic resonance imaging; histochemistry /cytochemistry; human tissue; microinjections; neural plasticity; neuroanatomy; pathologic process; structural biology; visual cortex; visual deprivation; visual fields

The primary goal of this project is to uncover physiological and anatomical correlates of amblyopia in both humans and monkeys. This will continue the P.I.'s previous grant concerning the structure of ocular dominance columns (ODC) in animals and humans. There are 5 new specific aims that he will investigate: (1) The effect of strabismus on periodicity of ocular dominance columns, (2) Possible disruption of intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations in human amblyopes of the complete pattern of ODC's, the organization of CO stripes in V2, and the organization of other extrastriate visual areas, (4) the cortical locus of visual suppression in strabismus and (5) the identity of a visual area anterior to macaque dorsal V2 that contains a unique CO pattern. Together, these new experiments will extend the previous work by investigating mechanisms beyond the ODC's that might be responsible for the poor vision in amblyopia.

该项目的主要目标是揭示生理和 人类和猴子弱视的解剖学相关性。这将 继续私家侦探先前关于眼部结构的研究 优势列（ODC）在动物和人类。 5个新的具体 他将研究的目的：（1）斜视对 眼优势柱的周期性，（2）眼优势柱的可能中断， V1中从层4C到层3的本征连接，（3）改变 在人类弱视的ODC的完整模式中， CO条纹的V2，和组织的其他纹外视觉 区域，（4）斜视中视觉抑制的皮质部位， (5)猕猴背V2前视觉区的身份， 含有独特的CO模式 这些新的实验将 通过调查ODC之外的机制来扩展以前的工作 这可能是导致弱视的原因。