MULTIPLE FORMS OF MEMORY STORAGE

描述(改编自调查者摘要)：计算模型 内存存储最近越来越受欢迎，因为它们 解释了在人类健忘症患者中观察到的各种结果。 这些模型还导致了关于赤字模式的两个预测 见于语义性痴呆症患者。此应用程序需要六个 几个月的支持，在一个特征良好的样本中测试这些预测 年在医学研究理事会对语义性痴呆患者的跟踪调查 英国剑桥。前两项研究同时使用外显和内隐两种方法 记忆探查对语义性痴呆患者的预测 应该更好地保存最近获得的语义知识 时间段比更偏远的时间段更长。后两项学习测试 当这些患者需要新的学习时，预测他们的新学习是完整的 用于语义精化的编码被最小化。这些研究考察了 两个本质上不同的进程的状态可以调解新的 学习，即回忆和熟悉。与 在健忘症患者中的现有发现，这些对患有健忘症患者的研究 语义性痴呆症将对当前的记忆模型进行强有力的测试 储存在人脑中。

DESCRIPTION (adapted from investigator's abstract): Computation models of memory storage have recently gained increased popularity because they account for a variety of findings observed in patients with human amnesia. These models also lead to two predictions regarding the pattern of deficits seen in patients with semantic dementia. This application requires six months of support to test these predictions in a well characterized sample of semantic dementia patients followed at the Medical Research Council in Cambridge, England. The first two studies use both explicit and implicit probes of memory to test the prediction that semantic dementia patients should show better preservation of semantic knowledge acquired in recent time periods than in more remote time periods. The second two studies test the prediction that new learning is intact in these patients when the need for semantic elaboration at encoding is minimized. These studies examine the status of two qualitatively different processes than can mediate new learning, namely recollection and familiarity. Taken together with the existing findings in patients with amnesia, these studies of patients with semantic dementia will provide a powerful test of current models of memory storage in the human brain.