INTEGRATION OF TASTE AND VISCERAL AFFERENT SIGNALS

味觉和内脏传入信号的整合

• 批准号: 2775299
• 负责人: JOHN-PAUL BAIRD
• 金额: $ 3.17万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2775299
• 关键词: behavioral /social science research tag; brain stem; chemical stimulation; cues; duodenum; gastrointestinal system; glucose; injection /infusion; laboratory rat; liver; mechanoreceptors; neural information processing; neuroregulation; nutrient intake activity; nutrition related tag; parabrachial nucleus; taste; visceral afferent nerve

Signals from the mouth and gut interact in the central nervous system to regulate ingestion. In the mouth, taste stimulation initially influences the decision to ingest and also promotes ongoing ingestion. In the gut, chemoreceptors and mechanoreceptors signal satiety, and thus help to suppress further intake. Behavioral studies show that ingestion is characterized by an inhibitory influence derived from an accumulating post-ingestive load that progressively counters the excitatory influence of taste on promoting ingestion. Mechanisms of this taste-visceral afferent integration are largely unknown, but likely involve neural signals reaching specific ventral nervous system loci, including the parabrachial nucleus (PBN), a site that receives strong convergent projects from second order taste and visceral afferents. The present series of experiments will test the hypothesis that the PBN is an important site for food intake regulation by determining (1) whether gastric and intestinal mechanoreceptor signals converge upon and modulate taste-sensitive neurons in the PBN, and (2) whether metabolic/nutrient-related signals from the liver and duodenum also influence taste-sensitive neurons in the PBN. Eating, metabolic and gastrointestinal disorders contribute to numerous diseases including hypertension, stroke and diabetes. An understanding of where and how taste and visceral signals are processed in the brain is fundamental to developing clinical interventions.

口腔和肠道的信号在中枢神经系统中相互作用以调节摄入。在口中，味道刺激最初会影响摄入的决定，并促进持续的摄入。在肠道中，化学感受器和机械感受器信号饱腹感，从而有助于抑制进一步的摄入量。行为研究表明，摄入的特征是抑制性影响源于积累的后载荷载荷，该负载逐渐抵消了味道对促进摄入的兴奋性影响。这种味道 - 野生传入的整合的机制在很大程度上是未知的，但可能涉及到达到特定腹神经系统基因座的神经信号，包括副核（PBN），该部位从二阶口味和内脏传入中接收强大的收敛性项目。 The present series of experiments will test the hypothesis that the PBN is an important site for food intake regulation by determining (1) whether gastric and intestinal mechanoreceptor signals converge upon and modulate taste-sensitive neurons in the PBN, and (2) whether metabolic/nutrient-related signals from the liver and duodenum also influence taste-sensitive neurons in the PBN.饮食，代谢和胃肠道疾病会导致许多疾病，包括高血压，中风和糖尿病。了解大脑中的味道和内脏信号的何处，味道和内脏信号是发展临床干预措施的基础。