TRAINING IN TRAUMA AND SEPSIS RESEARCH

创伤和脓毒症研究培训

• 批准号: 2720973
• 负责人: RICHARD L. SIMMONS
• 金额: $ 21.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2720973
• 关键词: TRAINING; TRAUMA; SEPSIS; RESEARCH

This postdoctoral training program proposal is designed to train fellows, principally surgeons, for a period of two-to-three years each, in basic science research relevant to trauma and sepsis. Funds to support a total of five positions each year (two new fellows each year, two second year positions, and one third-year) are requested. The overall research focus of the trainees is the molecular biology of the inflammatory response to injury. Three areas of research have been targeted: I) The molecular biology of hemorrhagic and traumatic shock; II) The regulation and function of nitric oxide in sepsis and trauma; and III) Mechanisms of immunoregulation in surgical patients. These areas coincide with current extramural research grants on which the faculty collaborate. The research plans are superb vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty is highly qualified, and all principle trainers have extramural research support and much training experience. Upon completion of the training program the fellow will understand how to design, carry out, and complete experiments to answer discrete biological questions derived from trauma victims and septic patients. The fellow will thus be trained, not simply in the sophisticated laboratory methodology in molecular biology, biochemistry, and cellular immunology, but also in the though processes to apply to future experimental problems. All trainees will have the opportunity to take formal academic courses offered by the basic science departments of the University of Pittsburgh and some will complete PhDs in the basic science departments. Most training will take place in the laboratories of the principle trainers who are all extramural grant-funded senior scientists in the areas of molecular biology, biochemistry, immunology, and cell biology, using a carefully though-out and well-proven modification of the master/apprentice system. The central training technique combines weekly one-on-one meetings between the apprentice and the trainer plus hour- long research training seminars twice weekly at which supervision subcommittees of four or five trainers, whose special skills supplement the friendly collaborative research and training simultaneously. The individual fellows choose a principle trainer and the Executive Training Committee tailors a fellowship supervising committee of faculty co- trainers to provide expert training necessary to supplement the talents of the principal trainer. Affirmative action recruitment efforts have already been very successful, and will continue; the training facilities can serve more fellows than will be funded by this training proposal. All the training can be carried out in the more than 50,000 square feet of fully equipped laboratory space available.

该博士后培训计划提案旨在培训研究员，主要是外科医生，每人为期两到三年，从事与创伤和败血症相关的基础科学研究。每年总共需要5个职位（每年2个新研究员，2个第二年职位，1个第三年职位）。受训者的整体研究重点是损伤炎症反应的分子生物学。主要研究三个领域：1)出血性休克和创伤性休克的分子生物学；II)一氧化氮在脓毒症和创伤中的调节和作用；III)外科患者免疫调节机制。这些领域与目前教师合作的校外研究补助金相吻合。研究计划是极好的培训工具，因为它们提出了广泛的问题，可以根据这些问题进行精确的、目标明确的个人研究培训。师资力量雄厚，所有主要培训师都有校外研究支持和丰富的培训经验。在完成培训计划后，研究员将了解如何设计，执行和完成实验，以回答来自创伤受害者和败血症患者的离散生物学问题。因此，研究员不仅要接受分子生物学、生物化学和细胞免疫学等复杂的实验室方法的培训，还要接受应用于未来实验问题的思考过程的培训。所有学员将有机会参加匹兹堡大学基础科学系开设的正式学术课程，部分学员将在基础科学系完成博士学位。大多数培训将在主要培训师的实验室进行，这些主要培训师都是由校外资助的分子生物学、生物化学、免疫学和细胞生物学领域的资深科学家，采用经过仔细考虑和充分证明的师徒制修改。培训的核心技术包括每周一对一的学徒与培训师会议，以及每周两次长达一小时的研究培训研讨会，由四到五名培训师组成的监督小组委员会，他们的特殊技能同时补充友好的合作研究和培训。每位受奖人选择一名主要训练师，执行训练委员会则会订定一个由教职员共同训练师组成的奖学金监督委员会，以提供必要的专家训练，以补充主要训练师的才能。平权行动招募工作已经非常成功，并将继续；培训设施可以为更多的研究员提供服务，而不是本培训提案所提供的资金。所有的培训都可以在超过5万平方英尺的设备齐全的实验室空间进行。