Training in Trauma, Inflammation, Sepsis and Critical Care

描述(由申请人提供)：本次竞争续签申请旨在支持德克萨斯大学西南医学中心(UT Southwest)在损伤、炎症和危重护理方面的研究培训计划。该提案旨在延长NIH资助的现有项目的工作，该项目在过去14年中一直得到资助。该计划的主要目标是培养长凳和内科科学家，他们将研究损伤和炎症的生物学和病理生理学中的关键问题，并将这些知识转化为危重患者管理方面的进步。这项创伤、败血症和炎症的基础研究工作的目标是开发新的治疗干预措施，以改善受伤患者的护理。该申请寻求继续支持每年三名博士后实习生(医学博士、医学博士/博士或博士)，每两年，重点是内科科学家。所追求的潜在调查水平是广泛的，可以在任何地方进行，从非常基础的研究到以患者为导向的研究，但培训将是严格的、结构化的，并直接适用于炎症性疾病。尽管最终的共同途径以多器官衰竭为特征，但输入的信息是可变的。在美国，损伤仍然是一个重要的健康问题，Parkland医院有一个主要的烧伤创伤和重症监护中心，这使得这项培训拨款的基础科学方面与损伤临床研究之间有了很大的协同作用。在接下来的几年里，我们的学员将接触到更广泛的临床和转化科学，因为我们的设施进行了新的损伤临床试验，包括GLUE赠款、复苏结果联盟(ROC)，以及由于Parkland纪念医院重症监护病房的新领导层而开发的多项新的重症监护试验。出于这些原因，我们建议扩大教学经验，将最近成立的临床科学系教授的临床研究课程包括在内。我们继续积极招聘博士和博士，以培养熟悉翻译研究的基础科学家，并提供一批博士干部，他们将在德克萨斯大学西南分校外科和儿科重症监护科担任教职。事实上，在上一次资助期间，我们已经聘请了这个项目的三名研究员中的两名作为外科系的教员。来自德克萨斯大学西南分校和位于德克萨斯大学西南校区的霍华德·休斯研究所的众多内科科学家的加入，为他们提供了大量国内和国际公认的科学家作为科学导师。这些变化大大加强了我们的目标。因此，我们计划的主要重点仍然是培养学员对基础科学的热情，为学员提供基础科学研究方面的最新技术进步，发展基础科学家和临床医生之间的密切合作研究努力，并最终开发新的治疗策略，用于临床领域。

DESCRIPTION (provided by applicant): This competitive renewal application seeks to support a research training program in injury, inflammation and critical care at the University of Texas Southwestern Medical Center (UT Southwestern). The proposal is designed to extend the work of the existing NIH funded program which has been funded for the last fourteen years. The primary goal of this program is to train bench and physician-scientists who will investigate key questions in the biology and pathophysiology of injury and inflammation and translate this knowledge into advances in the management of critically - ill patients. The object of this basic research effort in trauma, sepsis, and inflammation is to develop new and novel therapeutic interventions to improve the care of the injured patient. The application seeks to continue the support of three postdoctoral trainees (MD, MD/PhD, or PhD) per year for two years each, with an emphasis on physician scientists. The potential levels of investigation pursued are broad and may be conducted anywhere across the spectrum of very basic to patient-oriented research, but the training will be rigorous, structured, and directly applicable to inflammatory disease. Although the final common pathway is characterized by multi-organ failure, the inputs are variable. Injury remains an important health issue in the United States, and the presence of a major burn - trauma and critical care center at Parkland Hospital has allowed great synergy between the basic science aspects of this training grant and the clinical research in injury. In the upcoming years, our trainees will be exposed to a broader spectrum of clinical and translational science as a result of new clinical trials in injury in our facility, including the GLUE grant, Resuscitation Outcomes Consortium (ROC) as well as multiple new critical care trials developing as a consequence of new leadership in the intensive care unit at Parkland Memorial Hospital. For these reasons, we propose to expand the didactic experience to include clinical research courses taught by the recently created Department of Clinical Sciences. We continue to aggressively recruit both MDs and PhDs to produce basic scientists who are familiar with translational research and to provide a cadre of PhDs who will assume faculty positions within the surgery and pediatric critical care departments at UT Southwestern. In fact, we have hired two of the three fellows in this program during the last funding period as faculty members in the Department of Surgery. The inclusion of a broad range of physician scientists from UT Southwestern as well as the Howard Hughes Institute on the UT Southwestern campus provide a vast number of nationally and internationally recognized scientists to serve as scientific mentors. These changes significantly strengthen our objectives. Thus, the major focus of our program continues to be the development of enthusiasm for basic science among trainees, to provide trainees with the latest technical advances available in basic science research, to develop close collaborative research efforts between basic scientists and clinicians, and ultimately to develop new therapeutic strategies for application in the clinical arena.