Training in Trauma, Inflammation, Sepsis and Critical Care

描述（由申请人提供）：此竞争性更新申请旨在支持德克萨斯大学西南医学中心（UT西南）的损伤，炎症和重症监护研究培训计划。该提案旨在扩展现有的NIH资助项目的工作，该项目已经资助了14年。该计划的主要目标是培养实验室和内科科学家，他们将研究损伤和炎症的生物学和病理生理学中的关键问题，并将这些知识转化为危重病人管理的进步。这项在创伤、败血症和炎症方面的基础研究的目的是开发新的治疗干预措施，以改善受伤患者的护理。该申请旨在继续支持三名博士后培训生（医学博士，医学博士/博士，或博士），每年两年，重点是医师科学家。潜在的研究水平是广泛的，可以在非常基础的以患者为导向的研究范围内的任何地方进行，但培训将是严格的，结构化的，并直接适用于炎症性疾病。虽然最后的共同途径的特点是多器官衰竭，但输入是可变的。在美国，损伤仍然是一个重要的健康问题，在帕克兰医院有一个主要的烧伤创伤和重症护理中心，这使得这项培训拨款的基础科学方面和损伤的临床研究之间有了很大的协同作用。在接下来的几年里，我们的学员将接触到更广泛的临床和转化科学，这是我们设施中新的损伤临床试验的结果，包括GLUE赠款，复苏结果联盟（ROC），以及帕克兰纪念医院重症监护病房新领导所带来的多项新的重症监护试验。由于这些原因，我们建议扩大教学经验，包括最近成立的临床科学系教授的临床研究课程。我们继续积极招募医学博士和博士来培养熟悉转化研究的基础科学家，并提供一批博士骨干，他们将在德克萨斯大学西南分校的外科和儿科重症监护室担任教职。事实上，在最后一个资助期，我们已经聘请了这个项目的三位研究员中的两位作为外科部门的教员。包括来自UT西南大学以及UT西南校区霍华德休斯研究所的广泛内科科学家，提供了大量国内和国际公认的科学家作为科学导师。这些变化大大加强了我们的目标。因此，我们项目的主要重点仍然是培养学员对基础科学的热情，为学员提供基础科学研究领域的最新技术进展，发展基础科学家和临床医生之间的密切合作研究，最终开发新的治疗策略，应用于临床领域。

DESCRIPTION (provided by applicant): This competitive renewal application seeks to support a research training program in injury, inflammation and critical care at the University of Texas Southwestern Medical Center (UT Southwestern). The proposal is designed to extend the work of the existing NIH funded program which has been funded for the last fourteen years. The primary goal of this program is to train bench and physician-scientists who will investigate key questions in the biology and pathophysiology of injury and inflammation and translate this knowledge into advances in the management of critically - ill patients. The object of this basic research effort in trauma, sepsis, and inflammation is to develop new and novel therapeutic interventions to improve the care of the injured patient. The application seeks to continue the support of three postdoctoral trainees (MD, MD/PhD, or PhD) per year for two years each, with an emphasis on physician scientists. The potential levels of investigation pursued are broad and may be conducted anywhere across the spectrum of very basic to patient-oriented research, but the training will be rigorous, structured, and directly applicable to inflammatory disease. Although the final common pathway is characterized by multi-organ failure, the inputs are variable. Injury remains an important health issue in the United States, and the presence of a major burn - trauma and critical care center at Parkland Hospital has allowed great synergy between the basic science aspects of this training grant and the clinical research in injury. In the upcoming years, our trainees will be exposed to a broader spectrum of clinical and translational science as a result of new clinical trials in injury in our facility, including the GLUE grant, Resuscitation Outcomes Consortium (ROC) as well as multiple new critical care trials developing as a consequence of new leadership in the intensive care unit at Parkland Memorial Hospital. For these reasons, we propose to expand the didactic experience to include clinical research courses taught by the recently created Department of Clinical Sciences. We continue to aggressively recruit both MDs and PhDs to produce basic scientists who are familiar with translational research and to provide a cadre of PhDs who will assume faculty positions within the surgery and pediatric critical care departments at UT Southwestern. In fact, we have hired two of the three fellows in this program during the last funding period as faculty members in the Department of Surgery. The inclusion of a broad range of physician scientists from UT Southwestern as well as the Howard Hughes Institute on the UT Southwestern campus provide a vast number of nationally and internationally recognized scientists to serve as scientific mentors. These changes significantly strengthen our objectives. Thus, the major focus of our program continues to be the development of enthusiasm for basic science among trainees, to provide trainees with the latest technical advances available in basic science research, to develop close collaborative research efforts between basic scientists and clinicians, and ultimately to develop new therapeutic strategies for application in the clinical arena.