APPLIED BIOLOGY AND BIOPROCESS ENGINEERING TRAINING

应用生物学和生物工艺工程培训

• 批准号: 2721440
• 负责人: HARVEY W BLANCH
• 金额: $ 17万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-27 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2721440
• 关键词: APPLIED; BIOLOGY; BIOPROCESS; ENGINEERING; TRAINING

Purpose and Program Characteristics The purpose of this training program is to provide a curriculum and research environment that will prepare trainees in chemical engineering, chemistry and cell and molecular biology at the predoctoral level for careers in biotechnology. Specifically, this program focuses on research training in areas relevant to the needs of biotechnology, pharmaceutical and chemical companies currently involved in the manufacture of products using biological routes and includes areas such as molecular genetics, fermentation, mammalian cell culture, enzyme technology, bioproduct recovery, combinatorial biocatalysis, combinatorial chemistry. The graduate program includes laboratory and classroom instruction in cell culture techniques (mammalian and bacteria cell culture), protein and enzyme isolation, purification and immobilization, mutagenesis and gene expression, protein and nucleic acid chemistry and biochemistry, and separation and purification methods. This will be supplemented with seminar courses on current topics in industrial and scientific areas, including fermentations involving recombinant organisms, bioproduct recovery (including macromolecular separations), site-directed mutagenesis techniques, metabolic regulation, enzyme inhibitor design and the application of enzymes and antibodies as catalysts in organic syntheses. Lectures from internationally known guests in a variety of related disciplines will further enrich the training program. Research will be conducted in the various area described above under the supervision of the faculty mentors. Trainees Predoctoral students will enter the program with varying backgrounds, all holding Baccalaureate degrees in engineering or science (some with Masters degrees). They will be selected on the basis of undergraduate scholastic performance, scores on GRE tests and recommendations from faculty at their undergraduate institutions. Support for 12 trainees is requested. The average duration of the doctoral program in the participating departments is 5.5 years.

该培训计划的目的是提供一个课程和研究环境，为生物技术领域的职业生涯准备博士前水平的化学工程，化学，细胞和分子生物学学员。具体而言，该计划侧重于与生物技术，制药和化学公司目前参与使用生物路线制造产品的需求相关的领域的研究培训，包括分子遗传学，发酵，哺乳动物细胞培养，酶技术，生物产品回收，组合生物催化，组合化学等领域。研究生课程包括细胞培养技术（哺乳动物和细菌细胞培养），蛋白质和酶分离，纯化和固定化，诱变和基因表达，蛋白质和核酸化学和生物化学以及分离和纯化方法的实验室和课堂教学。这将辅之以关于工业和科学领域当前主题的研讨会课程，包括涉及重组有机体的发酵、生物产品回收（包括大分子分离）、定点诱变技术、代谢调节、酶抑制剂设计以及酶和抗体在有机合成中作为催化剂的应用。来自国际知名嘉宾的各种相关学科的讲座将进一步丰富培训计划。研究将在导师的监督下在上述各个领域进行。博士预科学生将进入不同背景的程序，所有持有学士学位的工程或科学（一些硕士学位）。他们将根据本科生的学习成绩、GRE考试成绩和本科院校教师的推荐来选择。需要为12名学员提供支持。参与部门的博士课程的平均持续时间为5.5年。