APPLIED BIOLOGY AND BIOPROCESS ENGINEERING TRAINING

应用生物学和生物工艺工程培训

• 批准号: 6150879
• 负责人: HARVEY W BLANCH
• 金额: $ 18.07万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-27 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6150879
• 关键词: APPLIED; BIOLOGY; BIOPROCESS; ENGINEERING; TRAINING

Purpose and Program Characteristics The purpose of this training program is to provide a curriculum and research environment that will prepare trainees in chemical engineering, chemistry and cell and molecular biology at the predoctoral level for careers in biotechnology. Specifically, this program focuses on research training in areas relevant to the needs of biotechnology, pharmaceutical and chemical companies currently involved in the manufacture of products using biological routes and includes areas such as molecular genetics, fermentation, mammalian cell culture, enzyme technology, bioproduct recovery, combinatorial biocatalysis, combinatorial chemistry. The graduate program includes laboratory and classroom instruction in cell culture techniques (mammalian and bacteria cell culture), protein and enzyme isolation, purification and immobilization, mutagenesis and gene expression, protein and nucleic acid chemistry and biochemistry, and separation and purification methods. This will be supplemented with seminar courses on current topics in industrial and scientific areas, including fermentations involving recombinant organisms, bioproduct recovery (including macromolecular separations), site-directed mutagenesis techniques, metabolic regulation, enzyme inhibitor design and the application of enzymes and antibodies as catalysts in organic syntheses. Lectures from internationally known guests in a variety of related disciplines will further enrich the training program. Research will be conducted in the various area described above under the supervision of the faculty mentors. Trainees Predoctoral students will enter the program with varying backgrounds, all holding Baccalaureate degrees in engineering or science (some with Masters degrees). They will be selected on the basis of undergraduate scholastic performance, scores on GRE tests and recommendations from faculty at their undergraduate institutions. Support for 12 trainees is requested. The average duration of the doctoral program in the participating departments is 5.5 years.

目的和项目特点 该培训项目的目的是提供一个课程和研究环境，为化学工程、化学以及细胞和分子生物学博士前水平的学员在生物技术领域的职业生涯做好准备。具体来说，该计划侧重于与目前参与生物途径产品制造的生物技术、制药和化学公司需求相关领域的研究培训，包括分子遗传学、发酵、哺乳动物细胞培养、酶技术、生物产品回收、组合生物催化、组合化学等领域。研究生课程包括细胞培养技术（哺乳动物和细菌细胞培养）、蛋白质和酶分离、纯化和固定、诱变和基因表达、蛋白质和核酸化学和生物化学以及分离和纯化方法的实验室和课堂教学。此外，还将辅以有关工业和科学领域当前主题的研讨会课程，包括涉及重组生物的发酵、生物产品回收（包括大分子分离）、定点诱变技术、代谢调节、酶抑制剂设计以及酶和抗体作为有机合成催化剂的应用。国际知名嘉宾在各个相关学科的讲座将进一步丰富培训内容。研究将在教师导师的监督下在上述各个领域进行。受训博士前学生将进入该计划，背景各异，全部拥有工程或科学学士学位（部分拥有硕士学位）。他们将根据本科生的学业成绩、GRE 考试成绩以及本科院校教师的推荐进行选拔。请求支持 12 名学员。参与院系的博士生平均修业年限为5.5年。