MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER

强迫症的分子遗传学

• 批准号: 6011915
• 负责人: Gregory L. HANNA
• 金额: $ 36.42万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6011915
• 关键词: chromosome walking; clinical research; disease /disorder onset; family genetics; gene expression; genetic markers; genetic screening; genetic susceptibility; genotype; human genetic material tag; human subject; linkage disequilibriums; linkage mapping; molecular genetics; nucleic acid sequence; obsessive compulsive disorder; polymerase chain reaction; statistics /biometry

DESCRIPTION (Adapted from the Investigator's Abstract): Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2.5 percent. Family studies indicate that OCD and sub-clinical obsessive-compulsive symptoms are familial. About one third of cases have onset by age 15 years. Recent family studies of OCS suggest that an early onset is associated with increased familial risk. The long-term goal of this project is to improve our understanding of the etiology of OCD by identifying susceptibility loci involved in early-onset OCD and determining the expression of these loci. An initial collection of families with early-onset OCD will be expanded through ascertainment of an additional 120 families with early-onset probands in which there is an affected sibling or second-degree relative. DNA from family members will be genotyped with mapped microsatellite markers and amplified by multiplex PCR spaced about every 10 cM. Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued.

描述(改编自《调查者摘要》)：强迫症 强迫症(OCD)是一种常见的精神疾病，终生患病率为 2.5%。家庭研究表明强迫症和亚临床 强迫症是家族性的。约三分之一的病例已发病 到15岁时。最近对OCS的家庭研究表明，早发性是 与增加的家族风险有关。这个项目的长期目标是 通过辨别强迫症的病因，提高我们对强迫症病因的认识 早发性强迫症的易感基因及其表达 这些基因座的。初步收集的早发性强迫症家庭将包括 通过确定另外120个早发性家庭进行了扩展 有受影响的兄弟姐妹或二级亲属的先证者。脱氧核糖核酸 将用绘制的微卫星标记对家庭成员进行基因分型 多重聚合酶链式反应扩增产物的间隔约为10 cM。参数和 将执行非参数链接分析。曾经有证据表明有关联 在早发性强迫症和遗传标记之间发现了更精确的基因 我们会继续推行本地化。