MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
批准号:
6186039
负责人:
Gregory L. HANNA
金额:
$35.49万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-08-15 至 2002-07-31
关键词:
chromosome walking clinical research disease /disorder onset family genetics gene expression genetic markers genetic screening genetic susceptibility genotype human genetic material tag human subject linkage disequilibriums linkage mapping molecular genetics nucleic acid sequence obsessive compulsive disorder polymerase chain reaction statistics /biometry
中文摘要
描述(改编自《调查者摘要》):强迫症
强迫症(OCD)是一种常见的精神疾病,终生患病率为
2.5%。家庭研究表明强迫症和亚临床
强迫症是家族性的。约三分之一的病例已发病
到15岁时。最近对OCS的家庭研究表明,早发性是
与增加的家族风险有关。这个项目的长期目标是
通过辨别强迫症的病因,提高我们对强迫症病因的认识
早发性强迫症的易感基因及其表达
这些基因座的。初步收集的早发性强迫症家庭将包括
通过确定另外120个早发性家庭进行了扩展
有受影响的兄弟姐妹或二级亲属的先证者。脱氧核糖核酸
将用绘制的微卫星标记对家庭成员进行基因分型
多重聚合酶链式反应扩增产物的间隔约为10 cM。参数和
将执行非参数链接分析。曾经有证据表明有关联
在早发性强迫症和遗传标记之间发现了更精确的基因
我们会继续推行本地化。
英文摘要
DESCRIPTION (Adapted from the Investigator's Abstract): Obsessive-compulsive
disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of
2.5 percent. Family studies indicate that OCD and sub-clinical
obsessive-compulsive symptoms are familial. About one third of cases have onset
by age 15 years. Recent family studies of OCS suggest that an early onset is
associated with increased familial risk. The long-term goal of this project is
to improve our understanding of the etiology of OCD by identifying
susceptibility loci involved in early-onset OCD and determining the expression
of these loci. An initial collection of families with early-onset OCD will be
expanded through ascertainment of an additional 120 families with early-onset
probands in which there is an affected sibling or second-degree relative. DNA
from family members will be genotyped with mapped microsatellite markers and
amplified by multiplex PCR spaced about every 10 cM. Parametric and
nonparametric linkage analyses will be performed. Once evidence for linkage
between early-onset OCD and a genetic marker is found, more precise gene
localization will be pursued.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
2/3-Brain Chemistry and Genetics in Pediatric Obsessive-Compulsive Disorder
-
批准号:8278047
-
项目类别:
-
资助金额:$38.5万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3 Brain Function and Genetics in Pediatric Obsessive-Compulsive Behaviors
-
批准号:9265510
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项目类别:
-
资助金额:$23.25万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3 Brain Function and Genetics in Pediatric Obsessive-Compulsive Behaviors
-
批准号:9098846
-
项目类别:
-
资助金额:$23.25万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3-Brain Chemistry and Genetics in Pediatric Obsessive-Compulsive Disorder
-
批准号:8076826
-
项目类别:
-
资助金额:$38.41万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3-Brain Chemistry and Genetics in Pediatric Obsessive-Compulsive Disorder
-
批准号:8444657
-
项目类别:
-
资助金额:$32.77万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3-Brain Chemistry and Genetics in Pediatric Obsessive-Compulsive Disorder
-
批准号:7930643
-
项目类别:
-
资助金额:$38.62万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
2/3-Brain Chemistry and Genetics in Pediatric Obsessive-Compulsive Disorder
-
批准号:7729292
-
项目类别:
-
资助金额:$38.7万
-
财政年份:2009
-
负责人:Gregory L. HANNA
-
依托单位:
MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
-
批准号:6011915
-
项目类别:
-
资助金额:$36.42万
-
财政年份:1999
-
负责人:Gregory L. HANNA
-
依托单位:
MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
-
批准号:6392352
-
项目类别:
-
资助金额:$37.62万
-
财政年份:1999
-
负责人:Gregory L. HANNA
-
依托单位:
GENETIC LINKAGE STUDY OF EARLY ONSET BIPOLAR DISORDER
-
批准号:6113503
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项目类别:
-
资助金额:$0.02万
-
财政年份:1998
-
负责人:Gregory L. HANNA
-
依托单位:
GENETIC LINKAGE STUDY OF EARLY ONSET BIPOLAR DISORDER
-
批准号:6297171
-
项目类别:
-
资助金额:$0.02万
-
财政年份:1998
-
负责人:Gregory L. HANNA
-
依托单位:
GENETIC LINKAGE STUDY OF EARLY ONSET BIPOLAR DISORDER
-
批准号:6274737
-
项目类别:
-
资助金额:$2.15万
-
财政年份:1997
-
负责人:Gregory L. HANNA
-
依托单位:
FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER
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批准号:2240424
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项目类别:
-
资助金额:$10.35万
-
财政年份:1993
-
负责人:Gregory L. HANNA
-
依托单位:
FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER
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批准号:2460269
-
项目类别:
-
资助金额:$10.89万
-
财政年份:1993
-
负责人:Gregory L. HANNA
-
依托单位:
FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER
-
批准号:3088969
-
项目类别:
-
资助金额:$9.83万
-
财政年份:1993
-
负责人:Gregory L. HANNA
-
依托单位:
FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER
-
批准号:2240423
-
项目类别:
-
资助金额:$10.08万
-
财政年份:1993
-
负责人:Gregory L. HANNA
-
依托单位:
FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER
-
批准号:2240425
-
项目类别:
-
资助金额:$10.61万
-
财政年份:1993
-
负责人:Gregory L. HANNA
-
依托单位:
海外基金