MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER

描述（改编自研究者摘要）：强迫症 强迫症（OCD）是一种常见的精神疾病， 2.5百分之家庭研究表明，强迫症和亚临床 强迫症是家族性的大约三分之一的病例是在 到15岁。最近的家庭研究表明，早期发病的OCS是 与家族风险增加有关。该项目的长期目标是 为了提高我们对强迫症病因的理解， 早发性强迫症易感基因的表达 这些地方。将收集早发强迫症家庭的初步资料， 通过确定另外120个早发性 先证者中有一个受影响的兄弟姐妹或二级亲属。DNA 将用微卫星标记进行基因分型， 通过间隔约每10 cM的多重PCR扩增。参数和 将进行非参数连锁分析。一旦有关联证据 在早发性强迫症和遗传标记之间找到了更精确的基因， 本地化将继续进行。

DESCRIPTION (Adapted from the Investigator's Abstract): Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2.5 percent. Family studies indicate that OCD and sub-clinical obsessive-compulsive symptoms are familial. About one third of cases have onset by age 15 years. Recent family studies of OCS suggest that an early onset is associated with increased familial risk. The long-term goal of this project is to improve our understanding of the etiology of OCD by identifying susceptibility loci involved in early-onset OCD and determining the expression of these loci. An initial collection of families with early-onset OCD will be expanded through ascertainment of an additional 120 families with early-onset probands in which there is an affected sibling or second-degree relative. DNA from family members will be genotyped with mapped microsatellite markers and amplified by multiplex PCR spaced about every 10 cM. Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued.