课题基金 / 基金详情

CLINICAL STUDIES OF COCAINE TOLERANCE, SENSITIZATION AND WITHDRAWAL

CLINICAL STUDIES OF COCAINE TOLERANCE, SENSITIZATION AND WITHDRAWAL
可卡因耐受性、致敏性和戒断的临床研究
批准号：
6201631
负责人：
Reese T. Jones
金额：
$40.85万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-08-01 至 2000-04-30
来源：
https://reporter.nih.gov/project-details/6201631
关键词：
behavioral /social science research tag behavioral habituation /sensitization clinical research clinical trials cocaine dopamine receptor drug abuse chemotherapy drug addiction antagonist drug habituation drug tolerance drug withdrawal human subject human therapy evaluation outcomes research pharmacokinetics phenylethylamines relapse /recurrence self medication

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英文摘要
This component of the proposed SPIRCAP describes two specific aims: 1. To screen clinically available agents that interfere with the acute neurochemical and behavioral responses to cocaine in behavioral, microdialysis and self-administration paradigms. Promising functional cocaine antagonists identified would subsequently be evaluated in human laboratory studies. 2. To screen clinically available pharmacotherapies that interfere with the sensitized response to repeated cocaine administration. In abstinent patients, such pharmacotherapies may protect against relapse to dependence by preventing a single episode of cocaine abuse from producing and especially intense subjective response.
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