DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM

描述(由申请人提供)： 此核心支持中心赠款(P30)应用程序请求为分析和合成化学实验室以及行政共享核心基础设施提供持续支持。参与的、目前得到资助的组成项目继续开展人体实验室和治疗诊所研究滥用药物的临床药理学、药物疗法和其他治疗药物滥用和成瘾的治疗策略的研究计划。参与项目感兴趣的药物包括烟草和尼古丁、可卡因、甲基苯丙胺和其他苯乙胺、麻黄生物碱、咖啡因、羟丁酸(GHB)、萨尔维诺林、腺苷、神经类固醇和阿片类药物。核心实验室已经开发和验证了分析方法，以支持这些药物的研究。其他分析方法和标记化合物将根据需要提供。参与项目和研究人员代表的学科包括精神病学、临床心理学、神经学、普通内科、心脏病学和临床药理学、精神药理学、毒理学、遗传学、儿科、药剂学、有机、药物和分析化学以及统计学。我们的目标是：(1)为加州大学旧金山分校和其他机构的药物滥用研究人员的参与项目提供最先进的、设备和人员齐全的分析和合成化学资源。(2)提供行政资源，用于编写手稿、IRB文件、数据处理和报告、赠款管理以及为参与项目提供服务所需的其他行政服务。(3)为参与项目提供研究设计和数据分析方面的统计咨询服务。长期目标是提供一个拥有充足的行政和实验室资源的设施，并提供稳定的支持，以便在个别资助的组成科学项目随着时间的推移而变化和演变时，对这些项目的需要作出反应。该设施是一个具有成本效益的共享实验室资源，它加强和扩展了目前由NIH或其他联邦或非联邦来源资助的调查人员的研究，以进一步了解人类精神活性药物的使用、滥用和成瘾、其健康后果及其管理。

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects include tobacco and nicotine, cocaine, methamphetamine and other phenethylamines, ephedra alkaloids, caffeine, gamma-hydroxybutyrate (GHB), salvinorin, adenosine, neurosteroids, and opiates. Analytical methods have been developed and validated in the core laboratory to support studies with these drugs. Other assays and labeled compounds will be made available as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) To provide a state-of-the-art, well equipped and staffed, analytical and synthetic chemistry resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative resources for preparation of manuscripts, IRB documents, and for data processing and reporting, grants management, and other administrative services needed to serve participating projects. (3) To provide statistical consulting services regarding study design and data analysis to participating projects. The long-term objective is to provide a facility with adequate administrative and laboratory resources with stability of support in order to be responsive to the needs of individual funded constituent scientific projects as they change and evolve over time. This facility is a cost-effective shared laboratory resource that enhances and extends research of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its management.