DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM

药物依赖性临床研究计划

• 批准号: 7425925
• 负责人: Reese T. Jones
• 金额: $ 61.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7425925
• 关键词: Adenosine; Alkaloids; Analytical Chemistry; Arts; Biological Assay; Caffeine; Cancer Center Support Grant; Cancer Grant Supplements (P30); Cardiology; Clinic; Clinical; Clinical Pharmacology; Clinical Psychology; Clinical Research; Cocaine; Consult; Data Analyses; Discipline; Drug Addiction; Drug abuse; Drug usage; Ephedra; Funding; Grant; Health; Human; Individual; Institution; Internal Medicine; Label; Laboratories; Manuscripts; Methamphetamine; Neurology; Nicotine; Opiates; Pediatrics; Pharmaceutical Preparations; Pharmacy facility; Phenethylamine; Phenethylamines; Preparation; Psychiatry; Psychopharmacology; Psychotropic Drugs; Reporting; Request for Applications; Research; Research Design; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Services; Source; Synthesis Chemistry; Time; Tobacco; Toxicogenetics; United States National Institutes of Health; addiction; analytical method; computerized data processing; cost; drug abuse chemotherapy; gamma hydroxybutyrate; interest; programs; statistics

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects include tobacco and nicotine, cocaine, methamphetamine and other phenethylamines, ephedra alkaloids, caffeine, gamma-hydroxybutyrate (GHB), salvinorin, adenosine, neurosteroids, and opiates. Analytical methods have been developed and validated in the core laboratory to support studies with these drugs. Other assays and labeled compounds will be made available as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) To provide a state-of-the-art, well equipped and staffed, analytical and synthetic chemistry resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative resources for preparation of manuscripts, IRB documents, and for data processing and reporting, grants management, and other administrative services needed to serve participating projects. (3) To provide statistical consulting services regarding study design and data analysis to participating projects. The long-term objective is to provide a facility with adequate administrative and laboratory resources with stability of support in order to be responsive to the needs of individual funded constituent scientific projects as they change and evolve over time. This facility is a cost-effective shared laboratory resource that enhances and extends research of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its management.

描述（由申请人提供）：