DRUG DEPENDENCE CLINICAL RESEARCH PROGRAM

药物依赖性临床研究计划

• 批准号: 6515672
• 负责人: Reese T. Jones
• 金额: $ 51.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515672
• 关键词: administrative personnel; analytical chemistry; biomedical facility; chemical synthesis; clinical research; cocaine; drug addiction; human data; methamphetamine; nicotine; statistical service /center; technical writing

We propose a P30 center to enhance and extend the effectiveness of currently funded human laboratory and treatment clinical research on the clinical pharmacology and pharmacotherapy of abused drugs. Our approach is multi-disciplinary, including investigators from psychiatry, psychopharmacology, clinical psychology, neurology, general internal medicine and clinical pharmacology, toxicology, dermatology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. The research focuses on the clinical pharmacology and pharmacotherapy of stimulant drugs; cocaine, methamphetamine, and nicotine. Individually funded projects enhanced the center's core resources include studies of the pharmacokinetics and pharmacodynamics of nicotine, nicotine kinetics in twin studies to investigate genetic susceptibility to nicotine addiction, pharmacokinetics of cocaine and methamphetamine in skin and hair with particular attention to understanding mechanisms for individual differences, innovative pharmacotherapies for cocaine addiction, and isradipine pharmacotherapy for methamphetamine addiction. The research involves only human subjects. This application requests support for a shared administrative and laboratory research infrastructure. Our aims are: 91) To provide a state-of-the-art analytical and synthetic chemistry resource for collaborative projects. (2) To provide administrative coordination and a resource for preparation of manuscripts, IRB submissions, grant applications fro data processing, and report preparation, coordination of research seminars, and other teaching and communication activities, grant management, and to carry out other administrative services required by the research teams. (3) To provide statistical services, particularly advice on study design and data analysis. The aim of the P30 center is to provide a facility with adequate administrative and scientific resources with stability of support and continuity as individually funded scientific projects change and evolve over time. This facility will be a cost-effective shared resource and will foster a synergistic approach and enhanced funded research to further our understanding of the clinical pharmacology of human psychoactive drug use, its health consequences and its management.

我们建议建立一个P30中心，以增强和扩大目前资助的人体实验室和治疗滥用药物的临床药理学和药物治疗的临床研究的有效性。我们的方法是多学科的，包括来自精神病学、精神药理学、临床心理学、神经病学、普通内科和临床药理学、毒理学、皮肤科、遗传学、儿科、药剂学、有机、药物和分析化学以及统计学的研究人员。这项研究的重点是兴奋剂的临床药理和药物治疗：可卡因、甲基苯丙胺和尼古丁。个人资助的项目加强了该中心的核心资源，包括尼古丁的药代动力学和药效学研究，尼古丁动力学的双胞胎研究，以调查尼古丁成瘾的遗传易感性，可卡因和甲基苯丙胺在皮肤和头发中的药代动力学，特别关注了解个体差异的机制，可卡因成瘾的创新药物疗法，以及甲基苯丙胺成瘾的伊拉地平药物疗法。这项研究只涉及人类受试者。该应用程序请求支持共享的管理和实验室研究基础设施。我们的目标是：91)为合作项目提供最先进的分析和合成化学资源。(2)提供行政协调和资源，用于准备手稿、IRB提交、用于数据处理的拨款申请、报告编写、协调研究研讨会和其他教学和交流活动、拨款管理，以及执行研究小组所需的其他行政服务。(3)提供统计服务，特别是研究设计和数据分析方面的建议。P30中心的目标是提供一个设施，拥有足够的行政和科学资源，随着个人资助的科学项目随着时间的推移而变化和发展，具有稳定的支持和连续性。这一设施将是一个具有成本效益的共享资源，并将促进协同方法和加强资助的研究，以促进我们对人类精神活性药物使用的临床药理学、其健康后果及其管理的理解。