EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS

该合同的主要目标是开展科学支持 国家毒理学计划跨机构中心的活动 替代毒理学方法的评估（中心）。 的 中心与机构间协调委员会密切合作 替代方法验证（ICCVAM）以促进开发， 验证、接受和使用新的替代测试方法以及 更能预测人类健康和生态的策略 效果优于现有的方法和策略。 方法有 寻求融合新的创新技术和科学 进步，并提供改进的毒性表征， 节省时间和成本，以及细化、减少和 替代动物用途。 该中心和 ICCVAM 的活动是 旨在评估新方法对特定风险的有用性 评估目的。 该中心协调科学同行评审 多机构新测试方法的跨机构考虑 兴趣，召开专家研讨会来评估验证状态 新方法并确定所需的研究和验证研究 填补关键知识空白，为 ICCVAM 及其特设测试方法专家工作组，预筛选测试 提交供审议的方法，传播测试信息 方法开发和验证，并支持中心的科学 咨询委员会。 合同的目标是提供 及时、反应灵敏、高质量、准确的行政管理， 开展这些活动需要技术和科学支持。

The major objective of this contract is to carry out scientific support activities for the National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (Center). The Center works closely with the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) to promote the development, validation, acceptance, and use of new alternative testing methods and strategies that will be more predictive of human health and ecological effects than currently available methods and strategies. Methods are sought that incorporate new innovative technologies and scientific advances, and that provide for improved toxicity characterization, savings in time and costs, and the refinement, reduction, and replacement of animal use. The Center and ICCVAM's activities are directed at assessing the usefulness of new methods for specific risk assessment purposes. The Center coordinates the scientific peer review and interagency consideration of new test methods of multi-agency interest, convenes expert workshops to evaluate the validation status of new methods and to identify research and validation studies needed to fill critical knowledge gaps, provides administrative support for the ICCVAM and its ad hoc Test Method Expert Working Groups, prescreens test methods submitted for consideration, disseminates information on test method development and validation, and supports the Center's Scientific Advisory Committee. The objective of the contract will be to provide timely, responsive, high quality, and accurate administrative, technical, and scientific support needed to carry out these activities.