EVALUATION OF ALTERNATIVE TOXICOLOGICAL METHODS

替代毒理学方法的评估

• 批准号: 6053866
• 负责人: RAYMOND R TICE
• 金额: $ 69.13万
• 依托单位: INTEGRATED LABORATORY SYSTEMS, LLC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-16 至 2001-04-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053866
• 关键词: evaluation /testing; health science research support; method development; technology /technique development; toxicant screening

The major objective of this contract is to carry out scientific support activities for the National Toxicology Program's Interagency Center for the Evaluation of Alternative Toxicological Methods (Center). The Center works closely with the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) to promote the development, validation, acceptance, and use of new alternative testing methods and strategies that will be more predictive of human health and ecological effects than currently available methods and strategies. Methods are sought that incorporate new innovative technologies and scientific advances, and that provide for improved toxicity characterization, savings in time and costs, and the refinement, reduction, and replacement of animal use. The Center and ICCVAM's activities are directed at assessing the usefulness of new methods for specific risk assessment purposes. The Center coordinates the scientific peer review and interagency consideration of new test methods of multi-agency interest, convenes expert workshops to evaluate the validation status of new methods and to identify research and validation studies needed to fill critical knowledge gaps, provides administrative support for the ICCVAM and its ad hoc Test Method Expert Working Groups, prescreens test methods submitted for consideration, disseminates information on test method development and validation, and supports the Center's Scientific Advisory Committee. The objective of the contract will be to provide timely, responsive, high quality, and accurate administrative, technical, and scientific support needed to carry out these activities.

这份合同的主要目标是进行科学保障 为国家毒理学计划机构间中心开展的活动 替代毒理学方法的评价(中心)。这个 中心与机构间协调委员会密切合作 验证替代方法(ICCVAM)以促进开发， 验证、验收和使用新的替代测试方法和 将更好地预测人类健康和生态的战略 效果比目前可用的方法和战略更好。方法是 寻求融合新的创新技术和科学 进展，并提供了改进的毒性表征， 节省时间和成本，以及改进、减少和 动物用途的替代。该中心和ICCVAM的活动包括 旨在评估针对特定风险的新方法的有效性 评估目的。该中心协调科学同行审查 以及对多机构新测试方法的跨机构考虑 感兴趣，召开专家研讨会评估验证状态 新方法，并确定所需的研究和验证研究 为填补关键的知识空白，为 ICCVAM及其特别测试方法专家工作组，预筛选测试 提交审议的方法，传播有关测试的信息 方法开发和验证，并支持中心的科学 咨询委员会。合同的目标将是提供 及时、灵敏、高质量、精准管理， 开展这些活动所需的技术和科学支持。