NITROSYL AND NITROSO COMPLEXES OF METALLOPORPHYRINS

金属卟啉的亚硝基和亚硝基配合物

• 批准号: 6019115
• 负责人: George Bannerman Richter-Addo
• 金额: $ 7.9万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6019115
• 关键词: X ray crystallography; active sites; chemical bond; chemical synthesis; chlorin; iron; metalloporphyrins; nitric oxide; nitrites; nitrosamines; nitroso compounds; ruthenium

Our efforts in the area of bioinorganic chemistry of nitric oxide (NO) are directed towards understanding how this small paramagnetic molecule functions in the chemistry of mammalian systems. The growth in interest in NO chemistry can be attributed to the discovery within the last several years that this remarkable small molecule is responsible for a host of biological phenomena such as the maintenance of normal blood pressure, neurotransmission, and DNA damage. Research in our laboratory involves the study of the fundamental chemistry of metal-NO linkages in biomolecules. No such studies have been done previously. Thus, the preparation of a series of NO complexes of metalloporphyrins (of varying electron-donating ability) and metallochlorins of some late first-row transition metals (Mn, Fe, Co) will be pursued. These metals are biologically active in a variety of ligand environments, and the NO complexes of metalloporphyrins/chlorins are potential models for heme-NO and cytochrome-NO interactions. The fundamental chemistry of the resulting product species with electrophilic and nucleophilic reagents to produce new sulfur-nitrogen, carbon-nitrogen, and nitrogen-nitrogen bonds will be investigated. The interaction of nitrosamines and thionitrites with the metalloporphyrins/chlorins will also be studied. Although nitrosamines are of environmental consequence and can be found in food and cigarette smoke, no studies have been conducted on how these carcinogenic molecules bind to metal complexes that may be present in the human body. Thus, the study of how the atoms in the nitrosamines bind to the metal centers in porphyrin-type compounds, and how these interactions control the eventual decomposition and/or activation pathways of the resulting biochemical species will be pivotal to developing new chemical routes for the deactivation of these carcinogens.

我们在一氧化氮（NO）生物无机化学领域的努力 旨在了解这种小的顺磁性分子 在哺乳动物系统中的化学功能。 兴趣的增长 在NO化学中，可以归因于最后一次发现 几年来，这种非凡的小分子负责 许多生物现象，如维持正常的血液 压力神经传递和DNA损伤 我们实验室的研究 涉及金属-NO键的基础化学研究， 生物分子 以前没有进行过这样的研究。 因此 制备一系列金属卟啉的NO络合物（不同的 供电子能力）和金属绿素的一些后期第一行 过渡金属（Mn、Fe、Co）将被追求。 这些金属 在各种配体环境中具有生物活性，并且NO 金属卟啉/二氢卟啉配合物是血红素-NO的潜在模型 和细胞色素-NO相互作用。 基础化学 用亲电和亲核试剂得到的产物物质 产生新的硫氮、碳氮和氮氮 债券将被调查。 亚硝胺与 还将研究具有金属卟啉/二氢卟酚的硫代亚硝酸盐。 虽然亚硝胺对环境有影响， 在食物和香烟烟雾中，没有研究表明这些 致癌分子与金属络合物结合， 人体的 因此，研究亚硝胺中的原子 结合到卟啉型化合物的金属中心，以及这些 相互作用控制最终的分解和/或活化 由此产生的生物化学物质的途径将是关键， 开发新的化学路线， 致癌物质。