MECHANISMS UNDERLYING MOTOR CORTEX PLASTICITY

运动皮层可塑性的机制

• 批准号: 6054490
• 负责人: GEORGE W. HUNTLEY
• 金额: $ 2.5万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6054490
• 关键词: NMDA receptors; brain stem; dizocilpine; electromyography; evoked potentials; facial nerve; inhibitor /antagonist; iontophoresis therapy; laboratory rat; microelectrodes; motor cortex; neural plasticity; neuroanatomy; neuronal transport; neuropharmacology; spinal cord; synapses; vibrissae

DESCRIPTION: (Applicant's abstract) The goal of this project is to determine the role of identified connections and specific glutamate receptors in the plasticity of adult motor cortex (MI) representations. The first hypothesis is that the forelimb/vibrissa border region contains overlapping distribution of output neurons to the spinal cord and facial nerve nucleus which could represent the anatomical basis for intracortical microstimulation (ICMS)-defected border shifts. Anterograde labelling from vibrissa cortex will be used to localize corticospinal terminations arising from vibrissa sites exhibiting a forelimb border shift. The second hypothesis is that the horizontal connections which cross between motor representations form an anatomical basis for rapid border shifts. A combination of ICMS and anterograde and retrograde tracer injections into the forelimb/vibrissa border region will be used to correlate the origin and topography of horizontal connections that cross map borders with respect to the location and limits of border shifts. This proposal will provide a comprehensive anatomical and functional basis of motor cortex plasticity which incorporates identified axonal pathways and specific glutamate receptor subunits.

描述：（申请人摘要）本项目的目标是 确定已识别的连接和特定谷氨酸的作用 受体的可塑性成年运动皮层（MI）的代表。 的 第一个假设是前肢/触须边缘区域包含 脊髓和面部的输出神经元的重叠分布 神经核，可以代表的解剖基础， 微刺激（ICMS）-缺陷边界移位。 顺行标记来自 触须皮质将用于定位皮质脊髓末梢， 前肢边缘移位的触须部位。 第二 一种假设是，运动之间的水平连接 表示形成了快速边界转移的解剖学基础。 一 ICMS与顺行和逆行示踪剂注射的组合 前肢/触须边界区域将用于将起源和 横向连接的地形，这些连接穿过地图边界， 边界变化的位置和范围。 该提案将提供一个 运动皮层可塑性的全面解剖和功能基础 它结合了已识别的轴突通路和特定的谷氨酸 受体亚单位