Training Program in Neuroscience

神经科学培训计划

• 批准号: 10618911
• 负责人: GEORGE W. HUNTLEY
• 金额: $ 32.12万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618911
• 关键词: Neurosciences; Training Programs

PROJECT SUMMARY This is the second renewal of Mount Sinai's Jointly Sponsored Institutional Predoctoral T32 Training Program in Neuroscience. The objective of the Training Program is to provide rigorous, broad-based, individualized and multidisciplinary training to Year 1 and 2 predoctoral students in basic, translational and clinical neuroscience research, thereby enhancing the ability of our trainees to acquire critical skillsets necessary for high-quality doctoral dissertation research and a productive and impactful career in the science- related workforce. To accomplish this, the Training Program leverages the intimate association between the Mount Sinai Hospital and Health System, the Icahn School of Medicine at Mount Sinai and Mount Sinai's Graduate School of Biomedical Sciences, physically embedded together under one leadership, to expose trainees to the enormous breadth of basic, translational and clinical scientific approaches and model systems represented by an outstanding training faculty, ranging from structure/function analysis of individual synapses, to computational modeling of gene, protein and connectivity networks in healthy and diseased brains, to behavioral, electrophysiological and imaging studies of a variety of organisms, including humans. Mount Sinai has undergone an enormous expansion in basic and clinical research infrastructure, neuroscience faculty recruitment and a 3-fold increase in applications to the Neuroscience PhD program. Thus, seven training slots per year are requested. Our trainees participate in an integrated program of Core courses (spanning genes, molecules, cells, synapses, circuits, systems, behaviors and brain pathophysiology) and includes a course with direct patient contact. Courses are team-taught by an exceptional faculty using different teaching styles, including flipped classrooms and other approaches. Additional first-year courses include Responsible Conduct in Research, Rigor and Reproducibiity, an intensive Biostatistics course (with a parallel lab in R-programming) a Journal Club/WIP and research rotations. By the end of the first year, trainees select a thesis lab, and during their second year, commence dissertation research while taking at least two Advanced Electives from a large number of courses offered across the Institution. This allows each trainee to customize their coursework to their particular research and training goal needs. Trainees in our program also benefit from numerous activities that enhance their research experience, including science theme-based Clubs, seminars, career development opportunities, teaching and peer-mentoring activities, an annual retreat and other cohesion-building events. This Neuroscience Training Program T32 is essential to Mount Sinai's mission of providing fundamental neuroscience research training to our students, and serves as the principal research training, mentoring and financial engine driving specifically early-stage predoctoral students seeking a PhD in Neuroscience.

项目概要 这是西奈山联合赞助机构博士前 T32 培训的第二次续签 神经科学计划。培训计划的目标是提供严格的、基础广泛的、 为一年级和二年级博士生提供基础、转化和基础方面的个性化和多学​​科培训 临床神经科学研究，从而提高学员获得关键技能的能力 对于高质量的博士论文研究和在科学领域富有成效和有影响力的职业生涯是必要的- 相关劳动力。为了实现这一目标，培训计划利用了 西奈山医院和卫生系统、西奈山伊坎医学院和西奈山医学院 生物医学科学研究生院，在一个领导下实际上整合在一起，以揭露 受训者将接触到广泛的基础、转化和临床科学方法和模型系统 以杰出的培训师为代表，范围从单个突触的结构/功能分析， 对健康和患病大脑中的基因、蛋白质和连接网络进行计算建模 对包括人类在内的多种生物体的行为、电生理学和成像研究。西奈山 基础和临床研究基础设施、神经科学学院经历了巨大的扩张 神经科学博士项目的招聘量和申请量增加了 3 倍。因此，七个训练槽 每年要求。我们的学员参加核心课程的综合计划（跨越基因、 分子、细胞、突触、电路、系统、行为和大脑病理生理学），并包括一门课程 直接接触患者。课程由杰出的教师团队使用不同的教学风格授课， 包括翻转课堂和其他方法。其他第一年课程包括负责任的行为 研究、严谨性和再现性，强化生物统计学课程（有 R 编程平行实验室） 期刊俱乐部/WIP 和研究轮换。在第一年结束时，学员选择一个论文实验室，并在期间 第二年，开始论文研究，同时从大型大学中至少选修两门高级选修课 整个机构提供的课程数量。这允许每个学员定制他们的课程作业 他们特定的研究和培训目标需求。我们计划的学员也从众多活动中受益 增强他们的研究经验，包括以科学为主题的俱乐部、研讨会、职业发展 机会、教学和同伴指导活动、年度务虚会和其他凝聚力建设活动。 这个神经科学培训计划 T32 对于西奈山提供基础的使命至关重要 为我们的学生提供神经科学研究培训，并作为主要的研究培训、指导和 金融引擎专门推动早期博士前学生寻求神经科学博士学位。

项目成果

Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types.

不同组织类型中 ATP 敏感 K 通道复合物的比较蛋白质组学分析。

• DOI: 10.1002/pmic.201200324
• 发表时间: 2013
• 期刊: Proteomics
• 影响因子: 3.4
• 作者: Kefaloyianni,Eirini;Lyssand,JohnS;Moreno,Cesar;Delaroche,Diane;Hong,Miyoun;Fenyö,David;Mobbs,CharlesV;Neubert,ThomasA;Coetzee,WilliamA
• 通讯作者: Coetzee,WilliamA

Hypothalamic EphA5 facilitates counterregulatory responses: possible role for bidirectional signaling leading to bistability that enhances responsiveness to hypoglycemia.

下丘脑 EphA5 促进反调节反应：双向信号传导可能发挥作用，导致双稳态，从而增强对低血糖的反应。

• DOI: 10.2337/db12-1735
• 发表时间: 2013
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Mobbs,CharlesV;Moreno,Cesar
• 通讯作者: Moreno,Cesar

Medial Prefrontal Cortex Reduces Memory Interference by Modifying Hippocampal Encoding.

• DOI: 10.1016/j.neuron.2017.03.011
• 发表时间: 2017-04-05
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Guise KG;Shapiro ML
• 通讯作者: Shapiro ML

Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens.

• DOI: 10.3389/fnmol.2016.00144
• 发表时间: 2016
• 期刊: Frontiers in molecular neuroscience
• 影响因子: 4.8
• 作者: Pfau ML;Purushothaman I;Feng J;Golden SA;Aleyasin H;Lorsch ZS;Cates HM;Flanigan ME;Menard C;Heshmati M;Wang Z;Ma'ayan A;Shen L;Hodes GE;Russo SJ
• 通讯作者: Russo SJ

Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.

• DOI: 10.3389/fnins.2023.1098441
• 发表时间: 2023
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Invernizzi, Azzurra;Rechtman, Elza;Oluyemi, Kristie;Renzetti, Stefano;Curtin, Paul;Colicino, Elena;Ambrosi, Claudia;Mascaro, Lorella;Patrono, Alessandra;Corbo, Daniele;Cagna, Giuseppa;Gasparotti, Roberto;Reichenberg, Abraham;Tang, Cheuk Y.;Smith, Donald R.;Placidi, Donatella;Lucchini, Roberto G.;Wright, Robert O.;Horton, Megan K.
• 通讯作者: Horton, Megan K.