FOLLICULAR DENDRITIC CELLS AND HIV PATHOGENESIS

滤泡树突细胞和 HIV 发病机制

• 批准号: 2887219
• 负责人: Gregory F. Burton
• 金额: $ 21.38万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 2000-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2887219
• 关键词: HIV infections; antibody receptor; apoptosis; complement receptor; dendritic cells; human immunodeficiency virus; human tissue; laboratory mouse; microorganism immunology; neutralizing antibody; polymerase chain reaction; tissue /cell culture; virus infection mechanism; zidovudine

DESCRIPTION: (Adapted from investigator's abstract) Large amounts of HIV are trapped on follicular dendritic cells (FDC) in the germinal centers of secondary lymphoid tissues. throughout clinical latency when CD+4 T cells continually decline, these germinal centers with virus-laden FDC, highly activated, CD+4 T cells and a state of high cellular activation are the primary sites of active HIV replication. The investigators hypothesize that FDC play a major role in HIv pathogenesis by: (1) serving as a reservoir of infectious HIV; (2) potentiating both de novo infection of newly entering cells and of latently infected cells coming into the germinal center; and (3) by permitting infection in the presence of high levels of neutralizing antibody. They also hypothesize that FDC features that promote infection may be able to be inhibited. In support of the hypothesis, they have recently shown that FDC trapped HIV immune complexes are highly infectious and they have data suggesting that FDC maintain HIV infectivity even in the absence of viral replication. They also have evidence that FDC promote a significant increase in the amount of HIV infection in both newly and latently infected T cells. Lastly they have found that FDC permit infection even in the presence of a vast excess of neutralizing antibody. The investigators believe that their hypothesis is exciting and that an understanding of FDC contributions to HIV pathogenesis will be critical in designing intervention strategies that can attack this reservoir of infectious virus. Current strategies to stop viral replication do not target the FDC reservoir which remains until the cells are destroyed and the lymph node involutes prior to the onset of AIDS. thus an understanding of FDC contributions may allow them to successfully target this important cell and its viral reservoir.

描述：（改编自研究者的摘要）大量的艾滋病毒