MRI IN VIVO DETECTION OF UNSTABLE ATHEROSCLEROTIC PLAQUE

不稳定动脉粥样硬化斑块的体内 MRI 检测

• 批准号: 6043927
• 负责人: CHUN YUAN
• 金额: $ 10.27万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6043927
• 关键词: atherosclerosis; atherosclerotic plaque; bioimaging /biomedical imaging; cardiovascular disorder diagnosis; carotid artery; cerebral ischemia /hypoxia; clinical research; diagnosis design /evaluation; endarterectomy; hemorrhage; histopathology; human subject; magnetic resonance imaging; myocardial ischemia /hypoxia; noninvasive diagnosis; prognosis; sign /symptom

DESCRIPTION high resolution magnetic resonance imaging (MRI) to identify the characteristics of carotid bifurcation atherosclerotic plaques and thus predict the clinical course of patients. The proposed studies will determine the sensitivity and specificity of in vivo MRI in the detection of plaque features at the human carotid bifurcation that are linked to plaque instability. High resolution MRI of the carotid artery immediately prior to carotid endarterectomy will allow direct correlation of MR images and histologic features. This in turn will lead to strategies for screening and follow-up of high risk individuals and would allow medical and surgical correction of unstable carotid plaques prior to the development of transient ischemic attacks or stroke. To determine whether MRI can determine if the fibrous cap of an atherosclerotic plaque is intact, different implementations of high resolution black blood imaging techniques will be used to identify and define differences in tissue contrast (including formation of a crater shape) on the luminal plaque surface and these MR images compared with histologic sections (Aim 1). Correlations between fibrous cap rupture, as detected by MRI, and increased ischemic neurologic symptoms, will be determined by the clinical presentation at the time of MR exam (including asymptomatic patients, presumably with less plaque rupture/symptoms), symptomatic status at the time of endarterectomy and histologic features (Aim 2). To determine whether MR images can identify new intraplaque hemorrhage (IH) and organized IH, different implementations of high resolution black blood imaging techniques will be used to identify the contrast features that differentiate IH from other tissues and new from organized IH and by comparison of these MR images with histologic sections (Aim 3). Finally, comparison of the MRI findings to the symptomatic status of the patient, including histology, will determine whether patients with a recent history of ischemic neurologic events show increased evidence of recent IH (Aim 4). A series of 150 surgery patients will be studied during the proposed 5-year studies. All the correlations between the MRI, histology and symptomatic status of each patient will be performed by independent observers, using a double-blind protocol. The accurate diagnosis of fibrous cap rupture and intraplaque hemorrhage/thrombus may have particular clinical relevance since these events are thought to precede and cause thromboembolic occlusion, which in the carotid artery, may result in stroke. These studies may eventually lead to the reliable visualization of the structural characteristics of advance lesions of carotid artery atherosclerosis in vivo which may provide a noninvasive mechanism to detect lesions that may place individuals at greater risk for stroke.

高分辨率磁共振成像（MRI）识别

项目成果

Enhanced image quality in black-blood MRI using the improved motion-sensitized driven-equilibrium (iMSDE) sequence.

• DOI: 10.1002/jmri.22149
• 发表时间: 2010-05
• 期刊: JOURNAL OF MAGNETIC RESONANCE IMAGING
• 影响因子: 4.4
• 作者: Wang, Jinnan;Yarnykh, Vasily L.;Yuan, Chun
• 通讯作者: Yuan, Chun

Closed contour edge detection of blood vessel lumen and outer wall boundaries in black-blood MR images.

• DOI: 10.1016/s0730-725x(98)00162-3
• 发表时间: 1999-02
• 期刊: Magnetic resonance imaging
• 影响因子: 2.5
• 作者: Chun Yuan;E. Lin;Jacob Millard;Jenq-Neng Hwang

Sex differences of high-risk carotid atherosclerotic plaque with less than 50% stenosis in asymptomatic patients: an in vivo 3T MRI study.

• DOI: 10.3174/ajnr.a3399
• 发表时间: 2013-05
• 期刊: AJNR. American journal of neuroradiology
• 作者: Ota H;Reeves MJ;Zhu DC;Majid A;Collar A;Yuan C;DeMarco JK
• 通讯作者: DeMarco JK

Minimization of MR contrast weightings for the comprehensive evaluation of carotid atherosclerotic disease.

• DOI: 10.1097/rli.0b013e3181beada7
• 发表时间: 2010-01
• 期刊: Investigative radiology
• 影响因子: 6.7
• 作者: Zhao X;Underhill HR;Yuan C;Oikawa M;Dong L;Ota H;Hatsukami TS;Wang Q;Ma L;Cai J
• 通讯作者: Cai J

MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T.

• DOI: 10.3174/ajnr.a2213
• 发表时间: 2010-09
• 期刊: AJNR. American journal of neuroradiology
• 作者: Demarco JK;Ota H;Underhill HR;Zhu DC;Reeves MJ;Potchen MJ;Majid A;Collar A;Talsma JA;Potru S;Oikawa M;Dong L;Zhao X;Yarnykh VL;Yuan C
• 通讯作者: Yuan C