PET AND THE FUNCTIONAL ANATOMY OF UNIPOLAR DEPRESSION

PET 与单极抑郁症的功能解剖学

• 批准号: 2890565
• 负责人: WAYNE C DREVETS
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2890565
• 关键词: antidepressants; bioimaging /biomedical imaging; brain circulation; brain metabolism; cerebrovascular imaging /visualization; human subject; longitudinal human study; magnetic resonance imaging; major depression; mental disorder chemotherapy; positron emission tomography

We will use PET measurements of regional cerebral blood flow (BF) and metabolism to characterize the functional anatomy of familial pure depressive disease (FPDD), a subtype of unipolar major depression. We will evaluate the hypotheses that BF is increased in the left prefrontal cortex, the left amygdala, and the left medial thalamus and decreased in the caudate during the depressed phase of FPDD. To distinguish the correlates of the depressive state from trait-abnormalities that may- underlie the tendency to become depressed, we will employ a longitudinal design in -which subjects are imaged in the unmedicated-depressed, medicated-depressed (after 2 weeks of antidepressant drug treatment), medicated-remitted (after 8 weeks of treatment), and unmedicated-remitted phases (14-24 mos. after the baseline scan). Intrasubject paired comparisons of the PET scans obtained in these four phases will also be used to examine the effects of antidepressant drugs on regional blood flow and metabolism. The physiologic measurements in the primary regions of interest will be accurately assessed using PET and magnetic resonance image (MRI) data for colocation and for correction for potential anatomical differences (related to affective disease or drug treatment) using an algorithm which assesses BF and metabolism per unit volume of tissue.

我们将使用PET测量局部脑血流量(BF)和 代谢对家族性纯净性骨质疏松症的功能解剖学特征 抑郁症(FPDD)，单相抑郁症的一种亚型。我们 我将评估左侧前额叶血流量增加的假设 大脑皮质、左侧杏仁核和左侧内侧丘脑，并在 FPDD减压期的尾状核。要区分 抑郁状态与特质异常之间的关系-- 在变得抑郁的趋势下，我们将采用纵向 设计--受试者在没有服药的情况下被成像--抑郁， 用药抑郁(在抗抑郁药物治疗2周后)， 用药后缓解(治疗8周后)，以及未用药后缓解 阶段(14-24个月在基线扫描之后)。子对象内配对 在这四个阶段中获得的PET扫描的比较也将是 用于检测抗抑郁药物对局部血液的影响 流动和新陈代谢。初级脑区的生理测量 将使用PET和磁共振对感兴趣的对象进行准确评估 用于托管和潜在校正的图像(MRI)数据 解剖学差异(与情感性疾病或药物治疗有关) 使用一种算法来评估BF和单位体积的新陈代谢 组织。