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AMPHETAMINE INDUCED 11C RACLOPRIDE DISPLACEMENT IN MOOD DISORDERS

AMPHETAMINE INDUCED 11C RACLOPRIDE DISPLACEMENT IN MOOD DISORDERS
安非他明引起心境障碍中的 11C 雷氯必利置换
批准号：
6264167
负责人：
WAYNE C DREVETS
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264167
关键词：
amphetamines clinical research dopamine drug interactions human subject major depression mood disorders neurochemistry pharmacokinetics positron emission tomography raclopride

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中文摘要
翻译
为了评估重度抑郁症（MDD）的中枢多巴胺能功能，将在基线时、安非他明（AMPH）诱导多巴胺（DA）释放后和α-甲基-对-酪氨酸诱导DA耗竭后，在对照和抑郁样本中采集11 C雷氯必利摄取的PET测量值。 在这些条件下的11 C-雷氯必利摄取将提供基线多巴胺D2/D3受体结合、内源性DA对这些受体的基线占有率和每个受试者样本中AMPH给药后释放的DA量的测量。 这些措施将在抑郁症和对照组之间进行比较，以检验MDD与腹侧纹状体DA浓度降低相关的假设。
英文摘要
To access central dopaminergic function in major depressive disorder (MDD), PET measures of 11C raclopride uptake will be acquired at baseline, after amphetamine (AMPH) induced dopamine (DA) release and following a-methyl-para-tyrosine induced DA depletion in control and depressed samples. The 11C-raclopride uptake in these conditions will provide measure of the baseline dopamine D2/D3 receptor binding, the baseline occupancy of these receptors by endogenous DA and the amount of DA released following AMPH administration in each subject sample. These measures will be compared between depressives and controls to test the hypothesis that MDD is associated with a reduction in ventral striatal DA concentrations.
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CEREBRAL 5HT1A RECEPTORS AND METABOLISM IN DEPRESSION
SEROTONIN 1A RECEPTOR AND METABOLIC IMAGING IN DEPRESSIO
AMPHETAMINE INDUCED 11C RACLOPRIDE DISPLACEMENT IN MOOD DISORDERS
CEREBRAL 5HT1A RECEPTORS AND METABOLISM IN DEPRESSION
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