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AMPHETAMINE INDUCED 11C RACLOPRIDE DISPLACEMENT IN MOOD DISORDERS

AMPHETAMINE INDUCED 11C RACLOPRIDE DISPLACEMENT IN MOOD DISORDERS
安非他明引起心境障碍中的 11C 雷氯必利置换
批准号：
6304640
负责人：
WAYNE C DREVETS
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6304640
关键词：
amphetamines clinical research dopamine drug interactions human subject major depression mood disorders neurochemistry pharmacokinetics positron emission tomography raclopride

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中文摘要
翻译
本研究的目的是评估重度抑郁障碍(MDD)患者的中枢多巴胺能功能。在安非他明(AMPH)诱导多巴胺(DA)释放和α-甲基对酪氨酸(AMPT)诱导DA耗竭后，在对照和抑郁样本中，将在基线时获得摄取[11C]-拉氯必利的PET测量结果。在这些条件下的11C-raclopide摄取将提供基线多巴胺D2/D3受体结合、内源性DA对这些受体的基线占有率以及在每个受试者样本中给予AMPH后DA的释放量的测量。这些测量将在抑郁症患者和对照组之间进行比较，以检验MDD与腹侧纹状体DA浓度降低相关的假设。
英文摘要
The objective of this study is to assess central dopaminergic function in major depressive disorder (MDD). PET measures of [11C]-raclopride uptake will be acquired at baseline, after amphetamine (AMPH)-induced dopamine (DA) release and following a-methyl-para-tyrosine (aMPT) induced DA depletion in control and depressed samples. The 11C-raclopride uptake in these conditions will provide measures of the baseline dopamine D2/D3 receptor binding, the baseline occupancy of these receptors by endogenous DA and the amount of DA released following AMPH administration in each subject sample. These measures will be compared between depressives and controls to test the hypothesis that MDD is associated with a reduction in ventral striatal DA concentrations.
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