NEURONAL DEVELOPMENT IN THE WING OF THE FRUITFLY

果蝇翅膀的神经元发育

基本信息

  • 批准号:
    2891766
  • 负责人:
  • 金额:
    $ 17.52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1990
  • 资助国家:
    美国
  • 起止时间:
    1990-08-01 至 2001-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: This proposal outlines a series of experiments designed to test and refine our understanding of the mechanisms by which the developing nervous system is precisely patterned. Such precision is essential to the normal functioning of the brain; the means by which such patterning arises is essential to both our understanding of normal fetal development, and for developing therapies for the recovery from disease and injury-induced trauma to the nervous system. The ability of researchers to experimentally analyze brain development in vertebrates, however, is limited by the complexity of the vertebrate nervous system and difficulties making appropriate experimental manipulations. This proposal therefore outlines an ongoing series of experiments which examine the patterned development of the peripheral nervous system in the wing of the fruitfly, Drosophila melanogaster. In the fruitfly wing, the individual elements of the PNS arise in an extremely stereotyped fashion from a single epithelial sheet. The relative simplicity of the system and the availability of a number of molecular and genetic tools make it very favorable for experimental analyses. We will use a combination of genetic, molecular, and immunohistological techniques to analyze the molecular basis of this stereotypy, concentrating especially on the sensory organs that arise along the anterior wing margin. Our analysis includes testing the roles of a number of known genes and cell signalling pathways, and continuing a search for novel genes critical to the patterning process. Our specific aims are to: 1. Examine the mechanisms underlying the formation of the dorsoventral compartment boundary. 2. Examine the role of the apterous boundary in localizing margin-specific gene expression; 3. Test the role of the margin-specific scalloped transcription factor in margin formation. 4. Test the role of the Notch signalling pathway in inducing margin wingless expression and neuronal development; 5. Examine the mechanisms by which wg can refine its domain of expression. 6) Examine the development and refinement of neural regions; 7) Screen for and characterize novel patterning genes using enhancer traps and the FLP-FRT Fl screening method.
描述:本提案概述了一系列旨在

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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SETH S BLAIR其他文献

SETH S BLAIR的其他文献

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{{ truncateString('SETH S BLAIR', 18)}}的其他基金

Regulation and feedback in Fat/Dachsous signaling
Fat/Dachsous 信号传导的调节和反馈
  • 批准号:
    10716713
  • 财政年份:
    2023
  • 资助金额:
    $ 17.52万
  • 项目类别:
Regulation of Hippo and PCP signaling by the protocadherins Fat and Dachsous
原钙粘蛋白 Fat 和 Dachsous 对 Hippo 和 PCP 信号传导的调节
  • 批准号:
    9923677
  • 财政年份:
    2017
  • 资助金额:
    $ 17.52万
  • 项目类别:
Fat-Dachsous signaling in growth control and planar cell polarity
生长控制和平面细胞极性中的脂肪-达克索信号传导
  • 批准号:
    8828794
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
Axes and compartments in the wing of the fruitfly
果蝇翅膀上的轴和隔间
  • 批准号:
    7204116
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
Axes and compartments in the wing of the fruitfly
果蝇翅膀上的轴和隔间
  • 批准号:
    7591604
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
NEURONAL DEVELOPMENT
神经元发育
  • 批准号:
    3414705
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
Compartment Boundaries in the Wing of the Fruitfly
果蝇翅膀的隔室边界
  • 批准号:
    6654351
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
NEURONAL DEVELOPMENT IN THE WING OF THE FRUITFLY
果蝇翅膀的神经元发育
  • 批准号:
    2445769
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
Compartment Boundaries in the Wing of the Fruitfly
果蝇翅膀的隔室边界
  • 批准号:
    6529516
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:
Axes and compartments in the wing of the fruitfly
果蝇翅膀上的轴和隔间
  • 批准号:
    7795696
  • 财政年份:
    1990
  • 资助金额:
    $ 17.52万
  • 项目类别:

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