MEDICAL CHEMISTRY--SYNTHESIS OF POTENTIAL TREATMENT

医学化学--潜在治疗方法的综合

• 批准号: 2893587
• 负责人: JOHN R CASHMAN
• 金额: --
• 依托单位: SEATTLE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-29 至 1999-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2893587
• 关键词: analog; cocaine; craving; dopamine antagonists; dopamine receptor; dopamine transporter; drug addiction antagonist; drug design /synthesis /production; drug screening /evaluation; neurotransmitter transport; serotonin inhibitor; substance abuse related behavior

One of the primary program objectives of the National Institute on Drug Abuse (NIDA) is to develop safe and effective medications which will eliminate craving and drug-seeking behavior in cocaine addicts. These drugs should either substitute for cocaine or antagonize its effects. At the present time, there is no safe and effective treatment available to eliminate or alleviate craving and drug-seeking behavior in cocaine addicts. This contract will provide a resource for NIDA to acquire new and innovative compounds for evaluation by MDD as potential treatment agents for cocaine abuse. It will also allow for the scale-up production, as well as production of analogs, of promising compounds resulting from this project and from past projects.

国家研究所的主要项目目标之一