ATTENTION IN AGING AND EARLY ALZHEIMERS DEMENTIA

描述(改编自调查人员摘要)：为了进一步 检查广泛的视觉和听觉领域的空间注意力 任务，提出了一个神经解剖学模型，假设 与不同方面相关的相互作用的皮质回路 在DAT中的选择性注意。一系列八项针对患者的研究 阿尔茨海默氏型痴呆症(DAT)、年龄匹配的对照组和 将对年轻的、年轻的和年老的成年人进行调查， 研究目的：(1)考察城市空间的功能特征 轻度痴呆DAT患者在广泛范围内的注意力 视觉、听觉和跨模式任务；(2)检查神经 DAT早期空间注意缺陷的机制；(3) 检查这些注意功能与年龄相关的变化，特别是 在旧的-旧的。对于第二个目标，正电子发射断层扫描(PET) 事件相关脑电位(ERPs)将用于揭示 空间注意的空间和时间特性 人类的大脑。PET将有助于识别大脑中受影响的区域 达特。ERPs将被用来研究空间的时间轨迹 注意DAT中的变化。

DESCRIPTION (Adapted from Investigator's Abstract): In order to further examine spatial attention across a broad range of visual and auditory tasks, a neuroanatomical model is proposed, postulating dysfunction of interacting corticocortical circuits associated with different aspects of selective attention in DAT. A series of eight studies in patients with dementia of the Alzheimer's type (DAT), age-matched controls, and young, "young-old" and "old-old" adults will be conducted, with the following aims: (1) To examine the functional characteristics of spatial attention in mildly demented DAT patients across a broad range of visual, auditory, and cross-modal tasks; (2) To examine the neural mechanisms underlying spatial attention deficits in early DAT; (3) To examine age-related changes in these attentional functions, particularly in the old-old. For the second aim, positron emission tomography (PET) and event-related brain potentials (ERPs) will be used to disclose spatial and temporal properties, respectively, of spatial attention in the human brain. PET will aid in identifying affected brain regions in DAT. ERPs will be used to investigate the temporal locus of spatial attention changes in DAT.