ATTENTION IN AGING AND EARLY ALZHEIMERS DEMENTIA

关注老龄化和早期阿尔茨海默病痴呆

• 批准号: 2899737
• 负责人: RAJA PARASURAMAN
• 金额: $ 21.29万
• 依托单位: CATHOLIC UNIVERSITY OF AMERICA
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2899737
• 关键词: Alzheimer's disease; aging; attention; auditory stimulus; brain disorder diagnosis; brain mapping; clinical research; cognition; dementia; early diagnosis; evoked potentials; human old age (65+); human subject; human very old age (85+); longitudinal human study; memory; neurobiology; neuropsychological tests; performance; positron emission tomography; space perception; temporal lobe /cortex; visual perception

DESCRIPTION (Adapted from Investigator's Abstract): In order to further examine spatial attention across a broad range of visual and auditory tasks, a neuroanatomical model is proposed, postulating dysfunction of interacting corticocortical circuits associated with different aspects of selective attention in DAT. A series of eight studies in patients with dementia of the Alzheimer's type (DAT), age-matched controls, and young, "young-old" and "old-old" adults will be conducted, with the following aims: (1) To examine the functional characteristics of spatial attention in mildly demented DAT patients across a broad range of visual, auditory, and cross-modal tasks; (2) To examine the neural mechanisms underlying spatial attention deficits in early DAT; (3) To examine age-related changes in these attentional functions, particularly in the old-old. For the second aim, positron emission tomography (PET) and event-related brain potentials (ERPs) will be used to disclose spatial and temporal properties, respectively, of spatial attention in the human brain. PET will aid in identifying affected brain regions in DAT. ERPs will be used to investigate the temporal locus of spatial attention changes in DAT.

描述（改编自研究者摘要）：为了进一步 在视觉和听觉的广泛范围内检查空间注意力 任务，提出了一个神经解剖模型，假设功能障碍， 与不同方面相关的相互作用的皮质回路 选择性注意的DAT。一系列的八项研究， 阿尔茨海默型痴呆（DAT），年龄匹配的对照， 年轻人，“老人”和“老人”的成年人将进行，与 以下目的：（1）研究空间的功能特征 在广泛的范围内，轻度痴呆DAT患者的注意力 视觉，听觉和跨通道任务;（2）检查神经元 早期DAT中空间注意力缺陷的潜在机制;（3）为了 研究这些注意力功能的年龄相关变化，特别是 在旧的。 对于第二个目标，正电子发射断层扫描（PET） 和事件相关脑电位（ERP）将被用来揭示 空间和时间属性，分别为空间注意， 人类的大脑 PET将有助于识别受影响的大脑区域， DAT。 ERPs将被用于研究空间的时间轨迹 注意DAT的变化。