Effects of attention and goal-state lapses on memory in healthy and pathological aging

注意力和目标状态失误对健康和病理衰老记忆的影响

• 批准号: 10369010
• 负责人: Anthony D Wagner
• 金额: $ 74.57万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10369010
• 关键词: Accounting; Address; Adopted; Adult; Affect; Age; Aging; Alzheimer disease detection; Alzheimer' s disease pathology; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Arousal; Attention; Behavioral; Behavioral Assay; Behavioral Sciences; Biological Assay; Biological Markers; Caliber; Categories; Code; Cognition; Cognitive; Color; Data; Disease; Elderly; Episodic memory; Functional Magnetic Resonance Imaging; Goals; Grain; Hippocampus (Brain); Individual; Individual Differences; Learning; Link; Location; Magnetic Resonance Imaging; Measures; Medial; Mediating; Memory; Memory Loss; Memory impairment; Molecular; Multivariate Analysis; Neurocognitive; Neurosciences; Pathology; Pattern; Performance; Positron-Emission Tomography; Probability; Process; Public Health; Pupil; Research; Resolution; Retrieval; Science; Short-Term Memory; Site; Sorting - Cell Movement; Source; Specific qualifier value; Stimulus; Structure; Temporal Lobe; age related; attentional control; base; cognitive neuroscience; distraction; functional magnetic resonance imaging/electroencephalography; healthy aging; indexing; innovation; innovative technologies; locus ceruleus structure; memory encoding; memory recognition; memory retrieval; multimodality; neural network; novel; novel marker; pathological aging; pre-clinical; psychologic; relating to nervous system; theories; tool; young adult; β-amyloid burden

Structural and functional changes in neural networks of attention and goal-directed cognition likely contribute to age-related memory decline and impede daily living. While considerable progress has been made in specifying how changes in the medial temporal lobe affect memory, moment-to-moment and individual differences in attention and goal-state representation are also hypothesized to impact episodic encoding and retrieval in young and older adults, and to contribute to age-related memory change. Of equal importance, in asymptomatic (`healthy') older adults, preclinical Alzheimer's disease (AD) pathology may disrupt attention and goal coding, with deleterious consequences for memory. Here, we aim to use innovative functional, molecular, and structural measures to characterize interactions between attention, goal states, and memory, and to examine (a) their contributions to trial-level, subject-level, and group-level memory differences, and (b) their relation to AD pathology. We will leverage goal-directed episodic encoding and retrieval paradigms and cutting-edge cognitive neuroscience tools, including task-based EEG-fMRI with pupillometry in asymptomatic (`healthy') older (65-79 yrs) and young adults (18-30 yrs). Trial-level attentional lapses will be assayed via fluctuations of alpha and theta oscillatory power and pupil diameter; the strength of trial-level goal states will be quantified via multivariate analyses of frontoparietal BOLD patterns. Aims 1-2 will address: How do interactions in attention and goal-state representation affect cortical and hippocampal mechanisms of episodic encoding (Aim 1) and retrieval (Aim 2), and how do age-related changes in these interactions relate to memory differences across age? Moreover, we will examine how molecular and structural biomarkers of pathological aging (AD) in `healthy' older adults relate to neural, pupillometry, and behavioral assays of attention, goal states, memory, and their interactions. Via PET-MR, we will measure (a) global β-amyloid (Aβ) burden and regional Aβ in frontoparietal cortex, and (b) locus coeruleus integrity, a core structure for attention, arousal, and goal-directed cognition, and an early site of AD pathology. Using categorical (Aβ+ vs. Aβ-) and continuous analyses, Aim 3 will address: Do molecular and structural biomarkers of pathology in preclinical aging predict differences in attentional lapses and goal coding, accounting for significant shared or unique variance in behavioral and neural measures of memory in asymptomatic individuals? The promise, feasibility, and novelty of the proposed research are grounded in strong preliminary data and derive from the use of multi-modal measures to discover how function, structure, and early pathology interact to affect attention, goal coding, and memory in aging. The project will advance understanding of (a) how moment-to- moment and individual differences in attention and goal coding affect learning and remembering in young and older adults, and (b) how these differences relate to memory decline in aging with and without AD pathology. The latter holds promise for revealing novel neurocognitive biomarkers of AD risk.

注意力和目标导向认知的神经网络的结构和功能变化可能有助于