LONGITUDINAL STUDIES OF ADULT COGNITIVE DEVELOPMENT

西雅图纵向研究（SLS）一直是监测成人认知发展的年龄和队列趋势的主要资源，为老年人使用的评估工具提供规范性数据，探索衰老个体差异的原因，并在纵向研究的背景下评估有针对性的认知干预的效果。目前，该项目一直资助到1998年，目的是研究健康史与认知功能维持之间的关系，提供另一项（1998年）纵向调查的随访，一项家庭研究的7年随访，以及认知训练研究的7年和14年随访。它还包括神经心理学测试，对700名60岁以上的受试者进行ApoE测试，以及招募最终尸检的受试者。目前的延续建议有四个组成部分：(1)完成第七波数据收集。正在寻求资金，以评估新的第七波840名受试者，并根据目前资助的纵向研究的后续数据收集进行分析。(2)在2000年（N = 500）和2003年（N = 400）每隔3年重复对60岁以上的老年小组成员进行神经心理评估，以获得更接近受试者死亡的测量值。(3)纵向小组成员的健康史将被更新到1998年，以评估行为-疾病关系随时间的变化。（4）. 家庭研究。将对第二代成员进行重新评估，以获得14年期间的数据（N = 800），并收集原始小组成员的600名孙子的数据，以便研究多代家庭认知相似性。将获得血液样本进行ApoE基因分型和脂质谱分析。

The Seattle Longitudinal Study (SLS) has been a major resource for monitoring age and cohort trends in adult cognitive development, providing normative data for assessment instruments used with older adults, exploring the causes of individual differences in aging, and assessing the effects of targeted cognitive interventions within the context of a longitudinal study. It is currently funded through 1998 to study the relation between health histories and maintenance of cognitive functioning, to provide another (1998) followup of the longitudinal panels, a 7-year follow-up of a family study, and 7- and 14-year follow-ups of the cognitive training studies. It also includes the administration of a neuropsychological battery, ApoE testing of 700 subjects over the age of 60, and recruitment of subjects for eventual autopsy. The present continuation proposal has four sub-components: (1) Completion of the 7th wave data collection. Funding is sought for the assessment of a new 7th wave of 840 subjects as well as for the analyses based on the currently funded follow-up data collection in the longitudinal study. (2) Neuro-psychological assessment obtained on older panel members over age 60 will be repeated in 3-year intervals in 2000 (N = 500) and 2003 (N = 400) to obtain measures closer to subjects' death. (3) Health histories of longitudinal panel members will be updated through 1998 to assess changes in behavior-disease relationships over time. (4). Family Studies. The second generation members will be reassessed to obtain data over a 14-year period (N = 800) and data will be collected on 600 grandchildren of the original panel member to allow studies of multi-generational family similarity in cognition. Blood samples will be obtained for ApoE genotyping and lipid profiles.