SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION

肿瘤细胞迁移中的信号转导和运动

• 批准号: 2837786
• 负责人: CHENG DONG
• 金额: $ 9.36万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-15 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2837786
• 关键词: biological signal transduction; calcium flux; calcium ion; cell line; cell migration; cell motility; cellular oncology; cytoskeleton; extracellular matrix; lipids; mathematical model; melanoma; metastasis; single cell analysis; stainings

The aims are: (1) to characterize the role of lipids in signal transduction by ECM molecules for tumor cell pseudopod protrusion and migration; (2) to determine the response of intracellular calcium cations in tumor cells to lipid-mediated ECM molecule stimulation; (3) to examine the response of the cytoskeletal actin network upon lipid- mediated ECM molecule stimulation during the two phase pseudopod protrusion; and (4) to construct a two phase pseudopod model integrating engineering sciences with cell biology and derive mechanistic parameters that may affect tumor cell migration.

目的是：（1）表征脂质在信号转导中的作用 通过ECM分子转导肿瘤细胞伪足突出， （2）测定细胞内钙离子的反应 肿瘤细胞中的阳离子对脂质介导的ECM分子刺激;（3） 研究细胞骨架肌动蛋白网络对脂质的反应， 介导的ECM分子刺激期间的两个阶段伪足 （4）建立了一个两相伪足模型， 工程科学与细胞生物学，并得出机械参数 这可能会影响肿瘤细胞的迁移。