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SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION

SIGNAL TRANSDUCTION AND MOTILITY IN TUMOR CELL MIGRATION
肿瘤细胞迁移中的信号转导和运动
批准号：
6329017
负责人：
CHENG DONG
金额：
$9.82万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-15 至 2002-11-30
来源：
https://reporter.nih.gov/project-details/6329017
关键词：
biological signal transduction calcium flux calcium ion cell line cell migration cell motility cellular oncology cytoskeleton extracellular matrix lipids mathematical model melanoma metastasis single cell analysis stainings

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英文摘要
The aims are: (1) to characterize the role of lipids in signal transduction by ECM molecules for tumor cell pseudopod protrusion and migration; (2) to determine the response of intracellular calcium cations in tumor cells to lipid-mediated ECM molecule stimulation; (3) to examine the response of the cytoskeletal actin network upon lipid- mediated ECM molecule stimulation during the two phase pseudopod protrusion; and (4) to construct a two phase pseudopod model integrating engineering sciences with cell biology and derive mechanistic parameters that may affect tumor cell migration.
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