POOLED ANALYSIS OF PROSPECTIVE ONCOLOGY ACADEMIC AWARD

应聘者：斯蒂芬妮·史密斯-华纳 获得流行病学博士学位，主修营养学 明尼苏达大学的流行病学博士。她被卷入了 进行多种类型的流行病学研究，并在以下方面有经验 研究设计、问卷开发、数据管理和 数据分析。史密斯-华纳博士对加强她的研究很感兴趣 作为独立研究人员在以下领域的背景和发展 癌症流行病学和营养流行病学。 环境：大卫·J·亨特博士，池塘项目现任负责人 项目，已同意成为这项提案的发起人。亨特医生已经 有指导研究生和博士后研究员的丰富经验 在不同的研究领域。此外，该署的首席调查员 包括在汇集项目中的个人研究对 扩大他们的合作，以评估饮食和肺癌的关联。 最后，哈佛大学公共学院营养系的教职员工 卫生部门和其他部门的科学家积极合作 机构。这种多方面的协作环境提供了独特的 进一步加强史密斯-华纳博士研究培训的机会。 研究建议：该建议建立在现有的汇集项目的基础上 前瞻性研究与癌症评估饮食与癌症的关系 肺癌是世界范围内死亡的主要原因。将数据池化来自 多项研究将使人们能够更准确地估计相关性和 对暴露和协变量进行更标准化的分类。从 组成这些分析的汇集项目的八项研究， 确诊约1,753例女性和1,945例男性肺癌 未雨绸缪。肺癌与水果和水果的关系 将对蔬菜进行评估，以确定特定的水果和 蔬菜，而不是总消费量，与肺的关系最大。 癌症风险。由于最近围绕该协会的争议 B-胡萝卜素与肺癌及其个体的关系 类胡萝卜素将被评估。与维生素A，C，E，脂肪， 胆固醇和酒精也将被评估。A方法开发目标 是使用对饮食多样性和饮食指数的新分析来检查 总体饮食的影响，而不是个别成分的影响。对于每次曝光 将审查吸烟状况和性别对效果的影响。这些 分析将充分利用已在 个人队列提供了强大的分析之间的关系 饮食和肺癌。

DESCRIPTION: (Applicant's Description) Candidate: Stephanie Smith-Warner received her doctoral degree in epidemiology, with a focus on nutritional epidemiology, from the University of Minnesota. She has been involved with the conduct of several types of epidemiologic studies and has experience in the areas of study design, questionnaire development, data management and data analysis. Dr. Smith-Warner is interested in strengthening her research background and development as an independent researcher in the fields of cancer epidemiology and nutritional epidemiology. Environment: Dr. David J. Hunter, the current Project Leader of the Pooling Project, has agreed to be the sponsor for this proposal. Dr. Hunter has extensive experience in mentoring graduate students and postdoctoral fellows in diverse areas of study. In addition, the Principal Investigators of the individual studies included in the Pooling Project are enthusiastic about expanding their collaboration to evaluate diet and lung cancer associations. Finally, faculty in the Nutrition Department at the Harvard School of Public Health actively collaborate with scientists in other departments and institutions. This multifaceted, collaborative environment provides unique opportunities for furthering Dr. Smith-Warner's research training. Research Proposal: This proposal builds upon the existing Pooling Project of Prospective Studies and Cancer to evaluate associations between diet and lung cancer, a leading cause of mortality worldwide. Pooling data from multiple studies will permit more precise estimation of the associations and more standardized categorization of exposures and covariates. From the eight studies comprising the Pooling Project for these analyses, approximately 1,753 female and 1,945 male lung cancer cases were ascertained prospectively. The association between lung cancer and fruits and vegetables will be evaluated to determine whether specific fruits and vegetables, rather than total consumption, are most strongly related to lung cancer risk. Due to the recent controversy surrounding the association between B-carotene and lung cancer, the relationship with individual carotenoids will be assessed. Relationships with vitamins A, C and E, fat, cholesterol and alcohol also will be evaluated. A methods development aim is to use new analyses of diet diversity and diet indices to examine the effects of total diet, rather than individual components. For each exposure effect modification by smoking status and gender will be examined. These analyses will take full advantage of extensive data already collected in the individual cohorts to provide a powerful analysis of the relation between diet and lung cancer.