POOLED ANALYSIS OF PROSPECTIVE ONCOLOGY ACADEMIC AWARD

前瞻性肿瘤学学术奖的汇总分析

• 批准号: 6376862
• 负责人: STEPHANIE A SMITH-WARNER
• 金额: $ 7.11万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-07 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376862
• 关键词: behavioral /social science research tag; breast neoplasms; clinical research; disease /disorder etiology; human subject; lung neoplasms; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; smoking; tobacco abuse

DESCRIPTION: (Applicant's Description) Candidate: Stephanie Smith-Warner received her doctoral degree in epidemiology, with a focus on nutritional epidemiology, from the University of Minnesota. She has been involved with the conduct of several types of epidemiologic studies and has experience in the areas of study design, questionnaire development, data management and data analysis. Dr. Smith-Warner is interested in strengthening her research background and development as an independent researcher in the fields of cancer epidemiology and nutritional epidemiology. Environment: Dr. David J. Hunter, the current Project Leader of the Pooling Project, has agreed to be the sponsor for this proposal. Dr. Hunter has extensive experience in mentoring graduate students and postdoctoral fellows in diverse areas of study. In addition, the Principal Investigators of the individual studies included in the Pooling Project are enthusiastic about expanding their collaboration to evaluate diet and lung cancer associations. Finally, faculty in the Nutrition Department at the Harvard School of Public Health actively collaborate with scientists in other departments and institutions. This multifaceted, collaborative environment provides unique opportunities for furthering Dr. Smith-Warner's research training. Research Proposal: This proposal builds upon the existing Pooling Project of Prospective Studies and Cancer to evaluate associations between diet and lung cancer, a leading cause of mortality worldwide. Pooling data from multiple studies will permit more precise estimation of the associations and more standardized categorization of exposures and covariates. From the eight studies comprising the Pooling Project for these analyses, approximately 1,753 female and 1,945 male lung cancer cases were ascertained prospectively. The association between lung cancer and fruits and vegetables will be evaluated to determine whether specific fruits and vegetables, rather than total consumption, are most strongly related to lung cancer risk. Due to the recent controversy surrounding the association between B-carotene and lung cancer, the relationship with individual carotenoids will be assessed. Relationships with vitamins A, C and E, fat, cholesterol and alcohol also will be evaluated. A methods development aim is to use new analyses of diet diversity and diet indices to examine the effects of total diet, rather than individual components. For each exposure effect modification by smoking status and gender will be examined. These analyses will take full advantage of extensive data already collected in the individual cohorts to provide a powerful analysis of the relation between diet and lung cancer.

描述：（申请人的描述）候选人：斯蒂芬妮史密斯-华纳 获得流行病学博士学位，重点是营养 流行病学，来自明尼苏达大学。 她参与了 进行了几种类型的流行病学研究，并有经验， 研究设计、问卷编制、数据管理和 数据分析 史密斯-华纳博士有兴趣加强她的研究 背景和发展作为一个独立的研究人员在各领域的 癌症流行病学和营养流行病学。 环境：大卫J.亨特博士，现任合并项目负责人 项目，已同意成为该提案的赞助商。 亨特医生 指导研究生和博士后研究员的丰富经验 在不同的研究领域。 此外，主要研究人员 汇集项目中包含的个别研究热衷于 扩大他们的合作，以评估饮食和肺癌的关联。 最后，哈佛公共管理学院营养系的教师们 卫生部积极与其他部门的科学家合作， 机构职能体系 这种多方面的协作环境提供了独特的 史密斯-华纳博士的进一步研究培训的机会。 研究提案：该提案建立在现有的池化项目基础上 前瞻性研究和癌症，以评估饮食和 肺癌是世界范围内的主要死亡原因。 汇总数据来自 多项研究将允许更精确地估计相关性， 暴露和协变量的更标准化分类。 从 八项研究组成了这些分析的汇集项目， 大约有1，753名女性和1，945名男性肺癌病例得到确认 前瞻性地。 肺癌与水果的关系 蔬菜将被评估，以确定是否特定的水果和 蔬菜，而不是总消费量，与肺的关系最密切 癌症风险。 由于最近围绕该协会的争议 β-胡萝卜素与肺癌的关系， 将评估类胡萝卜素。 与维生素A、C和E、脂肪、 胆固醇和酒精也将被评估。 方法开发目标 是使用新的饮食多样性和饮食指数分析， 整体饮食的影响，而不是个别成分。 针对各曝光 将检查吸烟状态和性别的影响。 这些 分析工作将充分利用已收集的大量数据， 个体队列提供了一个强有力的分析之间的关系 饮食与肺癌