INTERGENERATIONAL TRANSMISSION--SUBSTANCE ABUSE

这个高级科学家奖(K05)申请的首要目标是 为候选人提供一段稳定的资金时期，在这段时期内 开展全日制发展规划研究 生物行为因素的家族性传递模式 导致行为偏差的代际表现 和物质使用障碍(SUD)。新兴学科-- 发展精神病理学试图阐明病因， 当然，以及SUD、品行障碍等疾病的后遗症 和反社会人格障碍(ASPD) 整合来自多个学科的知识，如心理学、 精神病学、遗传学、流行病学和神经科学 发展导向。基础研究人员和理论家已经 假设关键的发展时期存在于特定的时期 家庭或独特的环境因素影响最大 确定一个不利的精神病理表型。有限 已经对关键事件的存在和时机进行了研究 CD、ASPD和SUD病因学的发展阶段 这些信息对于有效的时机和性质至关重要。 有针对性的药物滥用预防干预措施。拟议中的计划 的目的是进行系统的前瞻性研究 传播性与非传播性的本质及预测因素 行为异常、药物使用和肥皂水的发育风险 从青春期前开始，一直持续到 从童年过渡到青春期和青春期。这个 研究还将检查可传染性疾病的性别异质性 影响。性别异质性的存在是合理的，因为 已经描述了差异传输效应在相同的- 外化行为的性-亲子传播。这个 研究结果对预防药物滥用具有重要意义。

The overarching goal of this Senior Scientist Award (K05) application is to provide the candidate with a period of stable funding in which to conduct full-time programmatic research on the developmental patterning of familial transmission of biobehavioral factors that contribute to the transgenerational manifestations of conduct deviation and substance use disorders (SUD). The emerging discipline of developmental psychopathology attempts to elucidate the etiology, course, and sequelae of conditions such as SUD, Conduct Disorder (CD), and Antisocial Personality Disorder (ASPD) through the integration of knowledge from multiple disciplines such as psychology, psychiatry, genetics, epidemiology and neuroscience within a developmental orientation. Basic researchers and theorists have posited that critical developmental periods exist when particular familial or unique environmental factors are most influential in determining an adverse psychopathological phenotype. Limited research has been conducted on the presence and timing of critical developmental periods in the etiology of CD, ASPD and SUD, yet such information is vital to the efficacious timing and nature of targeted drug abuse prevention interventions. The proposed program of investigation aims to undertake systematic prospective research into the nature and predictors of transmissible and non-transmissible developmental risk for conduct deviancy, substance use and SUDs beginning in the prepubertal period and continuing across the transition from childhood to adolescence and young adulthood. The research will also examine sex heterogeneity of transmissible influences. The existence of sex heterogeneity is plausible since differential transmission effects have been described between same- sex-parent to child transmission for externalizing behaviors. The results have important implications for drug abuse prevention.