CORTICAL DIFFERENCES IN PATIENTS WITH ANTISOCIAL PERSONALITY DISORDER

反社会人格障碍患者的皮质差异

• 批准号: 8363460
• 负责人: MARINA BOCCARDI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363460
• 关键词: Affect; Antisocial Personality Disorder; Bilateral; Brain; Functional disorder; Funding; Grant; Individual; Investigation; Lateral; Left; Magnetic Resonance Imaging; Medial; Methods; Modeling; National Center for Research Resources; Patients; Pattern; Prefrontal Cortex; Principal Investigator; Research; Research Infrastructure; Resources; Sensory; Source; United States National Institutes of Health; association cortex; cerebral atrophy; computational anatomy; cost; gray matter; male; men; neuroimaging; psychopathic personality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Few neuroimaging studies have focused on antisocial personality disorder, however recent investigations suggest cortical thinning in the medial prefrontal cortex and lateral sensory and surrounding association cortices, as well as decreased volume in the prefrontal cortex and total brain. Methods: We aimed to identify anatomical patterns of cortical atrophy in 26 antisocial personality disorder males compared to 25 male healthy controls using magnetic resonance imaging volumetry and cortical pattern matching. Results: Antisocial personality disorder individuals as compared to healthy controls showed gray matter loss affecting bilateral medial prefrontal, orbitofrontal, cingulate and occipital, and left somatosensori cortices. Right occipital, left cingulate, and ventral orbitofrontal cortices loss were further pronounced in antisocial personality disorder individuals with high psychopathy respect to healthy controls than antisocial personality disorder individuals with low psychopathy compared to healthy controls. Conclusion: Men with antisocial personality disorder present cortical loss in orbitofrontal, medial prefrontal, cingulate and occipital regions compared to healthy individuals. Structural abnormalities on these regions may be implicated in the pathophysiology of antisocial personality disorder.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 背景资料：很少有神经影像学研究关注反社会人格障碍，但最近的研究表明，内侧前额叶皮层和外侧感觉和周围的联合皮层的皮质变薄，以及前额叶皮层和整个大脑的体积减少。 研究方法：我们的目的是确定26名反社会人格障碍男性与25名男性健康对照组相比，使用磁共振成像容量和皮质模式匹配的皮质萎缩的解剖模式。 结果如下：与健康对照组相比，反社会人格障碍患者的双侧内侧前额叶、眶额、扣带回和枕叶以及左侧躯体感觉皮质均出现灰质丢失。与健康对照组相比，具有高精神病性的反社会人格障碍个体的右枕叶、左扣带和腹侧眶额皮质损失比具有低精神病性的反社会人格障碍个体的损失更明显。 结论：与健康人相比，反社会人格障碍的男性在眶额、内侧前额叶、扣带回和枕叶区域存在皮质缺失。这些区域的结构异常可能与反社会人格障碍的病理生理学有关。