CORTICAL DIFFERENCES IN PATIENTS WITH ANTISOCIAL PERSONALITY DISORDER

反社会人格障碍患者的皮质差异

• 批准号: 8363460
• 负责人: MARINA BOCCARDI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363460
• 关键词: Affect; Antisocial Personality Disorder; Bilateral; Brain; Functional disorder; Funding; Grant; Individual; Investigation; Lateral; Left; Magnetic Resonance Imaging; Medial; Methods; Modeling; National Center for Research Resources; Patients; Pattern; Prefrontal Cortex; Principal Investigator; Research; Research Infrastructure; Resources; Sensory; Source; United States National Institutes of Health; association cortex; cerebral atrophy; computational anatomy; cost; gray matter; male; men; neuroimaging; psychopathic personality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Few neuroimaging studies have focused on antisocial personality disorder, however recent investigations suggest cortical thinning in the medial prefrontal cortex and lateral sensory and surrounding association cortices, as well as decreased volume in the prefrontal cortex and total brain. Methods: We aimed to identify anatomical patterns of cortical atrophy in 26 antisocial personality disorder males compared to 25 male healthy controls using magnetic resonance imaging volumetry and cortical pattern matching. Results: Antisocial personality disorder individuals as compared to healthy controls showed gray matter loss affecting bilateral medial prefrontal, orbitofrontal, cingulate and occipital, and left somatosensori cortices. Right occipital, left cingulate, and ventral orbitofrontal cortices loss were further pronounced in antisocial personality disorder individuals with high psychopathy respect to healthy controls than antisocial personality disorder individuals with low psychopathy compared to healthy controls. Conclusion: Men with antisocial personality disorder present cortical loss in orbitofrontal, medial prefrontal, cingulate and occipital regions compared to healthy individuals. Structural abnormalities on these regions may be implicated in the pathophysiology of antisocial personality disorder.

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