CORTICAL DIFFERENCES IN PATIENTS WITH ANTISOCIAL PERSONALITY DISORDER

反社会人格障碍患者的皮质差异

• 批准号: 8363460
• 负责人: MARINA BOCCARDI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363460
• 关键词: Affect; Antisocial Personality Disorder; Bilateral; Brain; Functional disorder; Funding; Grant; Individual; Investigation; Lateral; Left; Magnetic Resonance Imaging; Medial; Methods; Modeling; National Center for Research Resources; Patients; Pattern; Prefrontal Cortex; Principal Investigator; Research; Research Infrastructure; Resources; Sensory; Source; United States National Institutes of Health; association cortex; cerebral atrophy; computational anatomy; cost; gray matter; male; men; neuroimaging; psychopathic personality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: Few neuroimaging studies have focused on antisocial personality disorder, however recent investigations suggest cortical thinning in the medial prefrontal cortex and lateral sensory and surrounding association cortices, as well as decreased volume in the prefrontal cortex and total brain. Methods: We aimed to identify anatomical patterns of cortical atrophy in 26 antisocial personality disorder males compared to 25 male healthy controls using magnetic resonance imaging volumetry and cortical pattern matching. Results: Antisocial personality disorder individuals as compared to healthy controls showed gray matter loss affecting bilateral medial prefrontal, orbitofrontal, cingulate and occipital, and left somatosensori cortices. Right occipital, left cingulate, and ventral orbitofrontal cortices loss were further pronounced in antisocial personality disorder individuals with high psychopathy respect to healthy controls than antisocial personality disorder individuals with low psychopathy compared to healthy controls. Conclusion: Men with antisocial personality disorder present cortical loss in orbitofrontal, medial prefrontal, cingulate and occipital regions compared to healthy individuals. Structural abnormalities on these regions may be implicated in the pathophysiology of antisocial personality disorder.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景：很少有神经影像研究集中于反社会人格障碍，但最近的研究表明，内侧前额叶皮质和外侧感觉及周围联合皮质皮质变薄，前额叶皮质和全脑体积减少。 方法：采用磁共振成像、体积测量和皮质模式匹配的方法，对26例男性反社会性人格障碍患者和25例健康男性对照的大脑皮质萎缩解剖模式进行研究。 结果：与健康对照组相比，反社会人格障碍患者表现为双侧前额内侧、眶前叶、扣带回和枕叶的灰质丢失，以及左侧躯体感觉皮质。反社会人格障碍患者的右侧枕叶、左侧扣带回和腹侧眶前叶皮质的缺失在反社会人格障碍患者中表现得更为明显，与健康对照组相比，高精神病患者的右枕叶、左扣带回和腹侧眶前叶皮质的丢失更为明显。 结论：与健康人相比，反社会人格障碍患者在眶前叶、内侧前额叶、扣带回和枕叶区域出现皮质丢失。这些区域的结构异常可能与反社会人格障碍的病理生理学有关。