DRUG ABUSE AND IMPULSIVITY--TESTS OF AN ANIMAL MODEL
DRUG ABUSE AND IMPULSIVITY--TESTS OF AN ANIMAL MODEL
批准号:
2898074
负责人:
Jerry B Richards
金额:
$11.12万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-09-01 至 2001-06-30
中文摘要
描述(申请人摘要):
这个项目的总体目标是开发一种敏感的、准确的
确定了冲动行为的动物模型。该模型基于
假设冲动的个体对延迟相对不敏感
和/或不确定的后果(奖惩)。人民币贬值
延迟和/或不确定的后果会导致冲动的人
相对更多地受到直接确定的后果的影响。模型
以“贴现”价值衡量对后果的敏感度
冲动的人对延迟的和/或不确定的价值贴现
奖励和惩罚的人比不冲动的人多。在动物身上
对延迟和/或不确定后果的价值进行评估
在大鼠体内进行定量检测。提出了八个实验来评估
折扣程序的可靠性和有效性。为了验证
在模型中,导致人类冲动行为的操作将是
测试过。因此,5-羟色胺(5-羟色胺)损伤的影响;以及给药
安非他明、乙醇和安定将在所有8个实验中进行测试。
实验1和实验2为对照实验,将评估其可靠性
不同奖罚额的程序。它是
预测5HT病变和药物不会影响折扣
实验1和实验2,因为这些实验不涉及延迟或
不确定性。实验3和实验4检验了价值的折现
通过拖延来奖励和惩罚后果。实验5和实验6检验
不确定因素对奖惩后果的贴现。
实验7和实验8检验奖励和惩罚的折扣
由于延误和不确定性的共同作用而产生的后果。据预测,
5-羟色胺损伤和安非他明、乙醇和安定会增加
实验3、4、5、6、7、8.建立动物模型
人类冲动行为的研究将使研究人员能够更系统地
探索冲动行为的神经化学和药理学基础。
英文摘要
DESCRIPTION (Applicant's Abstract):
The overall goal of this project is to develop a sensitive, precisely
defined animal model of impulsive behavior. The model is based on the
assumption that impulsive individuals are relatively insensitive to delayed
and/or uncertain consequences (rewards and punishers). Devaluation of
delayed and/or uncertain consequences causes impulsive individuals to be
relatively more influenced by immediate certain consequences. The model
measures sensitivity to consequences in terms of "discounted" value such
that impulsive individuals discount the value of delayed and/or uncertain
rewards and punishers more then nonimpulsive individuals. In the animal
model the value of delayed and/or uncertain consequences is assessed
quantitatively in rats. Eight experiments are proposed to asses the
reliability and validity of the discounting procedure. In order to validate
the model, manipulations which cause impulsive behaviors in humans will be
tested. Thus, the effects of serotonin (5HT) lesions; and administration of
amphetamine, ethanol and diazepam will be tested in all 8 experiments.
Experiments 1 & 2 are control experiments which will assess the reliability
of the procedure with different amounts of reward and punishment. It is
predicted that 5HT lesions and drugs will not affect discounting in
Experiments 1 & 2 because these experiments do not involve delay or
uncertainty. Experiments 3 & 4 examine discounting of the value of
rewarding and punishing consequences by delay. Experiments 5 & 6 examine
discounting of rewarding and punishing consequences by uncertainty.
Experiments 7 & 8 examine discounting of rewarding and punishing
consequences by the combination of delay and uncertainty. It is predicted
that 5HT lesions and amphetamine, ethanol, and diazepam will increase
discounting in experiments 3, 4, 5, 6, 7, & 8. Establishing an animal model
of impulsive human behavior will enable researchers to more systematically
explore the neurochemical and pharmacological basis of impulsive behavior.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Center for Genetic Studies of Drug Abuse in Outbred Rats
-
批准号:10160849
-
项目类别:
-
资助金额:$36.19万
-
财政年份:2014
-
负责人:Jerry B Richards
-
依托单位:
Center for Genetic Studies of Drug Abuse in Outbred Rats
-
批准号:10613540
-
项目类别:
-
资助金额:$21.78万
-
财政年份:2014
-
负责人:Jerry B Richards
-
依托单位:
Center for Genetic Studies of Drug Abuse in Outbred Rats
-
批准号:10402312
-
项目类别:
-
资助金额:$36.19万
-
财政年份:2014
-
负责人:Jerry B Richards
-
依托单位:
Effects of Negative Consequences on Drug Self Administration in Rats
-
批准号:7641471
-
项目类别:
-
资助金额:$23.05万
-
财政年份:2009
-
负责人:Jerry B Richards
-
依托单位:
Models of Impulsive Behavior in Mice
-
批准号:6345519
-
项目类别:
-
资助金额:$14.57万
-
财政年份:2001
-
负责人:Jerry B Richards
-
依托单位:
Models of Impulsive Behavior in Mice
-
批准号:6634366
-
项目类别:
-
资助金额:$15.68万
-
财政年份:2001
-
负责人:Jerry B Richards
-
依托单位:
Models of Impulsive Behavior in Mice
-
批准号:6515891
-
项目类别:
-
资助金额:$15.58万
-
财政年份:2001
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity : Tests of Animal Models
-
批准号:6913737
-
项目类别:
-
资助金额:$15.02万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity: Tests of Animal Models
-
批准号:7894880
-
项目类别:
-
资助金额:$27.74万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
DRUG ABUSE AND IMPULSIVITY--TESTS OF AN ANIMAL MODEL
-
批准号:2770145
-
项目类别:
-
资助金额:$10.69万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
DRUG ABUSE AND IMPULSIVITY--TESTS OF AN ANIMAL MODEL
-
批准号:2518004
-
项目类别:
-
资助金额:$10.25万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity: Tests of Animal Models
-
批准号:7581918
-
项目类别:
-
资助金额:$27.74万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity : Tests of Animal Models
-
批准号:6768718
-
项目类别:
-
资助金额:$15.3万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity : Tests of Animal Models
-
批准号:6383927
-
项目类别:
-
资助金额:$15.5万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity : Tests of Animal Models
-
批准号:6515567
-
项目类别:
-
资助金额:$15.6万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Drug Abuse and Impulsivity : Tests of Animal Models
-
批准号:6605893
-
项目类别:
-
资助金额:$15.7万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
DRUG ABUSE AND IMPULSIVITY--TESTS OF AN ANIMAL MODEL
-
批准号:2123984
-
项目类别:
-
资助金额:$10.14万
-
财政年份:1996
-
负责人:Jerry B Richards
-
依托单位:
Center for Genetic Studies of Drug Abuse in Outbred Rats
-
批准号:9793607
-
项目类别:
-
资助金额:$34.08万
-
财政年份:--
-
负责人:Jerry B Richards
-
依托单位:
海外基金