OTOACOUSTIC EMISSION COCHLEOGRAPHY

描述：拟议实验的主要目标是 畸变产物耳声发射（DPOAEs）是研究更多 影响该领域的基本 了解几个相对较新开发的措施， 抑制和延迟。 另一个目的是开始识别 DPOAE生成过程的解剖学对应物。 具体来说，一 明确的目标是确定抑制调谐曲线是否提供了一种测量 耳蜗创伤或DPOAE产生部位的指示。 另一 具体的目的是确定基底毛细胞的贡献， （OHC）在小型实验室动物和人类中的观察结果 Q位以上DPOAE的抑制和增强。 进一步的目标是 确定是否系统性诱导DPOAE潜伏期测量的变化 反映耳蜗过滤和/或耳蜗内 DPOAE生成过程。 最后一个具体目标是开始确定 OFIC的静纤毛的状态有助于 高电平DPOAE发生器，如果改变抑制调谐表现出 一些实验动物在噪声暴露后， 位于正常外毛细胞的基底部。 拟议的研究将是 使用人和实验室兔以平行方式进行 科目 基本的实验计划是进行批判性的比较 在正常耳和病理耳中产生的DPOAE之间， 暂时或永久性地改变或暴露于过度的声音， 使用耳毒性药物呋塞米。 的结果 计划中的实验将有助于我们的知识库， DPOAE产生的基本过程，DPOAE的身份 有可能在临床上有用的措施，以及DPOAE的相关性 在实验室哺乳动物中的世代与在人类中的世代。

DESCRIPTION: The primary goal of the proposed experiments on distortion-produc otoacoustic emissions (DPOAEs) is to investigate more completely particular issues that impact the field's fundamental understanding of several relatively recently developed measures of suppression and latency. An additional aim is t begin to identify the anatomical counterparts of the DPOAE-generation process. Specifically, one explicit goal is to determine if suppression-tuning curves provide a measure of cochlear trauma, or indication of the DPOAE generation site(s). Another specific aim is to determine the contribution that basal oute hair cells (OHCs) make to the observations in small laboratory animals and humans of suppression and enhancement of the DPOAE above the Q place. A furthe aim is to establish if systematically induced changes in DPOAE latency measure reflect alterations in cochlear filtering and/or build-up of the DPOAE-generation process. A final specific aim is to begin to determine if the status of the OFIC's stereocilia contribute to the viability of high-level DPOAE generator, and if the altered suppression tuning exhibited by some experimental animals following noise exposure is associated with more basally located regions of normal OHCs. The proposed studies will be performed in a parallel manner using both human and laboratory-rabbit subjects. The basic experimental plan is to make critical comparisons between DPOAEs generated in normal and pathological ears that have been temporarily or permanently altered by either exposure to excessive sounds or the administration of the ototoxic drug furosemide. The results of the planned experiments will contribute to out knowledge base concerning the basic processes underlying the production of DPOAEs, the identity of DPOAE measures that promise to be clinically useful, and the relevance of DPOAE generation in laboratory mammals to that in humans.