OTOACOUSTIC EMISSION COCHLEOGRAPHY

失真产物辐射(DPE)已被证明是敏感的 耳蜗机能指标。这些产品的几个功能 特殊的耳声发射使它们成为 进行性听力损失的测量。因此，DPE似乎 独一无二地测试外毛细胞功能，它们只需简单测量 通过将微型麦克风系统插入外耳 而且他们可以精确地测量耳朵对微妙的反应 刺激频率和强度的梯度。所有这些都是积极的 这些特点表明，DPE有朝一日可能会成为对 听力受损。我们最近进行的一项小规模试点研究的结果 在听力正常和听力受损的耳朵上都完成 支持DPE在临床环境中的潜在效用。这个 目前的研究建议首先将我们的初始数据库扩展到 包括对正常听力受试者进行更大范围抽样，以便 可以进行可靠的描述性统计分析。 “正常”耳朵的个体变异性来源将是 通过将DPE与其他排放类型和罚款联系起来进行调查- 听证解决措施。此外，统计和 将对技术程序进行调查，以评估其 降低DPE措施和相关措施的变异性的有效性 噪声地板，以增加响应的动态范围 测量。其次，患者群体代表了几个常见的 进行性听力障碍将接受DPEs测试，以便 将这些测量与频率模式和程度联系起来 听力损失。还将尝试确定是否 听力障碍的病因对DPE有显著影响 结果。最后，选定的患者将在 要求5年的项目期，以建立DPE的能力 描述他们进行性听力损失的过程。

Distortion-product emissions (DPEs) have been shown to be sensitive indicators of cochlear function. Several features of these particular otacoustic emissions make them important candidates for the measurement of progressive hearing loss. Thus, DPEs appear to uniquely test outer hair-cell function, they are simply measured by inserting a miniature microphone system into the external ear canal, and they can precisely measure the ear's response to subtle gradations in stimulus frequency and intensity. All these positive features suggest that DPEs may someday become a powerful test of hearing impairment. The outcome of a small pilot study we recently completed on both normally hearing and hearing-impaired ears supports the potential utility of DPEs in a clinical setting. The present study proposes first to extend our initial data base to include a larger sampling of normal hearing subjects so that reliable descriptive statistical analyses can be performed. Sources of individual variability in "normal" ears will be investigated by relating DPEs to other emission types and fine- resolution measures of hearing. In addition, statistical and technical procedures will be investigated to assess their effectiveness in reducing variability in DPE measures and related noise floors in order to increase the dynamic range of the response measure. Secondly, patient populations representing several common progressive-hearing disorders will be tested for DPEs in order to relate these measures to the frequency pattern and degree of hearing loss. An attempt will also be made to determine if the etiology of the hearing disorder significantly influences the DPE results. Finally, selected patients will be monitored over the requested 5-yr project period to establish the ability of DPEs to describe the course of their progressive-hearing losses.