GLUCOSE SENSITIVE ARTIFICIAL RECEPTORS FOR INSULIN

描述(改编自申请人的摘要)： 理论上讲，胰岛素依赖型(I型)糖尿病可以通过 注射胰岛素。不幸的是，目前的周期方法 胰岛素注射提供的胰岛素与正常的胰岛素非常接近。 输出。胰岛素在血液循环中的反馈控制释放 一种可用于将血糖浓度维持在 所需级别。这项初步研究(R21应用)旨在 展示了一种新方法在合成新类型化合物中的实用性 用于人工胰腺开发的聚合物材料。 具体地说，在此应用模型中，将执行研究以构建 能够将葡萄糖结合物结合在这种聚合物上的聚合物受体 感受器。如果申请人能够成功地证明 这个概念，它开启了将相同的方法用于 糖基化胰岛素聚合物受体的合成。这种聚合物， 如果成功开发，可以被用作可植入的 人工胰腺。

DESCRIPTION (Adapted from applicant's abstract): The symptoms of insulin-dependent (type I) diabetes could theoretically be corrected by the administration of insulin. Unfortunately, the current method of periodic insulin injection provides a poor approximation of the normal insulin output. Feedback controlled release of insulin into blood circulation is one approach that can be used to maintain blood glucose concentrations at desired levels. This pilot study (R21 application) is aimed at demonstrating the utility of a novel approach to the syntheses of new types of polymeric materials for the development of an artificial pancreas. Specifically, in this application model studies will be performed to build polymeric receptors that can bind the glucose conjugates on such polymeric receptors. If the applicant can successfully demonstrate the feasibility of the concept, it opens the possibility of using the same method for the syntheses of polymeric receptors for glycosylated insulin. Such polymers, if successfully developed, could conceivably be used as an implantable artificial pancreas.