APPLICATION OF TWO FACILE RELEASE SYSTEMS

本项目涉及两种简易环化系统的应用。 用于开发氧化还原敏感的有机保护基 综合。应用这种简易环化系统的可行性 在多肽合成方面也将进行研究。因为顺畅的环化 体系在温和的还原条件下被裂解，它们可以被 选择性地去除，通常不影响其他官能团 见于有机化合物和多肽中。因此，这提供了一种 保护策略，这与其他可用的方法是正交的。 努力将重点放在测试应用的实际可行性上 这两个简单的环化系统在有机和多肽的合成中。

This project involves the application of two facile cyclization systems for the development of redox-sensitive protecting groups for organic synthesis. The feasibility of applying such facile cyclization systems in peptide synthesis will also be studied. Because the facile cyclization systems are cleaved under mild reductive conditions, they can be selectively removed without affecting other functional groups commonly seen in organic compounds and peptides. Therefore, this provides a protecting strategy, which is orthogonal to other methods available. Efforts will he focused on testing the practical feasibility of applying these two facile cyclization systems in organic and peptide syntheses.