PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS

描述：(改编自调查员摘要)： 这是一个建议，以表征肾上腺皮质适应 围产期缺氧。在具体目标1-3中，适应 新生儿和新生儿出生前和出生后缺氧的恢复和恢复 幼年大鼠将通过测量血浆激素浓度进行研究 和电解质，体外醛固酮的生成，表达 类固醇生成酶基因和线粒体的组织形态计量学。 具体目标4将确定ACTH增加是否是 大鼠脑内醛固酮合成途径对低氧的适应 新生大鼠。具体目标5将决定是否发生戏剧性变化 发生在低氧哺乳大鼠体内的血浆脂类是主要的 对醛固酮合成的影响。

DESCRIPTION: (Adapted from investigator's abstract): This is a proposal to characterize the adrenocortical adaptation to hypoxia in the perinatal period. In specific aims 1-3, the adaptation to and recovery from pre- and postnatal hypoxia in the neonatal and juvenile rat will be studied by measuring plasma hormone concentrations and electrolytes, aldosteroidogenesis in vitro, the expression of steroidogenic enzyme mRNA's, and mitochondrial histomorphometry. Specific aim 4 will determine if increased ACTH is a major mechanism in the adaptation of the aldosteroidogenic pathway to hypoxia in the neonatal rat. Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis.