PERINATAL HYPOXIA--ADRENOCORTICAL/METABOLIC ADAPTATIONS

描述：（改编自研究者摘要）： 这是一个建议，以表征肾上腺皮质适应， 围产期缺氧。在具体目标1-3中， 新生儿出生前和出生后缺氧的恢复， 将通过测量血浆激素浓度来研究幼年大鼠 和电解质，体外醛固酮合成， 类固醇生成酶mRNA和线粒体组织形态计量学。 具体目标4将确定ACTH增加是否是 醛固酮生成途径对缺氧的适应性 新生大鼠具体目标5将决定 在缺氧乳鼠中出现的血浆脂质是一种主要的 对醛固酮生成影响。

DESCRIPTION: (Adapted from investigator's abstract): This is a proposal to characterize the adrenocortical adaptation to hypoxia in the perinatal period. In specific aims 1-3, the adaptation to and recovery from pre- and postnatal hypoxia in the neonatal and juvenile rat will be studied by measuring plasma hormone concentrations and electrolytes, aldosteroidogenesis in vitro, the expression of steroidogenic enzyme mRNA's, and mitochondrial histomorphometry. Specific aim 4 will determine if increased ACTH is a major mechanism in the adaptation of the aldosteroidogenic pathway to hypoxia in the neonatal rat. Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis.