SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
批准号:
2763507
负责人:
WILLIAM E RENEHAN
金额:
$20.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-01-01 至 2002-12-31
关键词:
amygdala appetite regulatory center bombesin like peptide corticotropin releasing factor electrophysiology endogenous opioid galanin gamma aminobutyrate gastrointestinal absorption /transport hypothalamus incretin hormone laboratory rat microinjections neural transmission neurons neuropeptide Y neurophysiology nutrient intake activity oxytocin prosencephalon satiations vagus nerve
中文摘要
描述(申请人摘要):
英文摘要
DESCRIPTION (applicant's abstract):
Disorders of appetite and feeding (including anorexia nervosa and
bulimia nervosa) can have a profound impact on the quality of life and
may even contribute to or cause death. Recent data indicate that certain
forebrain structures, such as the hypothalamus and amygdala, play a
particularly important role in feeding behavior. Unfortunately, while
it is clear that these forebrain regions are important in the regulation
of feeding, we know very little about the mechanism(s) of this
regulation. Our preliminary studies, however, indicate that the
hypothalamus and the amygdala have the ability to dramatically modify
the response properties of neurons in the dorsal vagal complex.
Increased or decreased activity in these descending pathways to the
dorsal vagal complex has the potential to alter ascending satiety
signals, modulate the cephalic phase of feeding and affect the
absorption of nutrients from the gastrointestinal tract. Our data
suggest that most gut-sensitive neurons in the nucleus of the solitary
tract (NST) are inhibited by electrical stimulation of the
paraventricular nucleus of the hypothalamus (PVN). We postulate that the
NST neurons that are inhibited by the PVN will exhibit this response
when the PVN is injected with neuropeptide Y (NPY) and/or galanin (GAL),
with this influence mediated by the release of GAL from GAL-positive PVN
neurons that terminate in the NST. We propose that the subset of NST
neurons that is excited by the PVN will exhibit this response when the
PVN is injected with corticotropin releasing hormone (CRH) and/or
glucagon-like peptide-1 (GLP-1) and hypothesize that the excitatory
influence of the PVN on the NST is mediated by bombesin-like peptides
(BN-LP). Our data indicate that most of the NST neurons that respond to
stimulation of the central nucleus of the amygdala (Ce) are inhibited
by this input and we propose that these NST neurons will exhibit this
response when the Ce is injected with GAL. We will demonstrate whether
the Ce's inhibition of the NST is mediated by gamma-aminobutyric acid
(GABA) and/or endogenous opioids. Finally, we will examine the response
properties of gastric- and intestine-sensitive DMNV neurons that are
modulated by descending inputs from the PVN. Our preliminary data
indicate that the PVN inputs to the DMNV are primarily excitatory. We
postulate that the DMNV neurons that are excited by the PVN will exhibit
this response when the PVN is injected with NPY and/or GAL, an effect
that we believe is mediated by oxytocin (OT). We will test these
hypotheses with three Specific Aims that will employ a combination of
extracellular and intracellular recording, intracellular labeling,
microinjection of four peptides into the forebrain and picospritzer
injection of multiple receptor agonists and antagonists in the dorsal
vagal complex. Our goal is to provide data that will contribute to our
understanding of the mechanisms underlying feeding behavior as well as
form a foundation for future behavioral and pharmacological studies
designed to ameliorate the devastating effects of feeding disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SCIENTIFIC REVIEW & EVALUATION AWARD--NIDR SPECIAL GRANT
-
批准号:2133162
-
项目类别:
-
资助金额:$45.0万
-
财政年份:1995
-
负责人:WILLIAM E RENEHAN
-
依托单位:
SCIENTIFIC REVIEW & EVALUATION AWARD--NIDR SPECIAL GRANT
-
批准号:2133161
-
项目类别:
-
资助金额:$45.0万
-
财政年份:1995
-
负责人:WILLIAM E RENEHAN
-
依托单位:
SCIENTIFIC REVIEW & EVALUATION AWARD--NIDR SPECIAL GRANT
-
批准号:2638386
-
项目类别:
-
资助金额:$45.87万
-
财政年份:1995
-
负责人:WILLIAM E RENEHAN
-
依托单位:
SCIENTIFIC REVIEW & EVALUATION AWARD--NIDR SPECIAL GRANT
-
批准号:2822331
-
项目类别:
-
资助金额:$3.22万
-
财政年份:1995
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE/FUNCTION RELATIONSHIP OF BRAINSTEM TASTE CELLS
-
批准号:2126227
-
项目类别:
-
资助金额:$15.76万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE RELATIONSHIPS OF BRAINSTEM TASTE CELLS
-
批准号:2126229
-
项目类别:
-
资助金额:$20.37万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE RELATIONSHIPS OF BRAINSTEM TASTE CELLS
-
批准号:2900035
-
项目类别:
-
资助金额:$22.13万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE FUNCTION RELATIONSHIPS IN BRAINSTEM TASTE CELL
-
批准号:6379292
-
项目类别:
-
资助金额:$32.52万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE RELATIONSHIPS OF BRAINSTEM TASTE CELLS
-
批准号:2683914
-
项目类别:
-
资助金额:$21.74万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE-FUNCTION RELATIONSHIP OF BRAINSTEM TASTE CELLS
-
批准号:3217785
-
项目类别:
-
资助金额:$14.51万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE RELATIONSHIPS OF BRAINSTEM TASTE CELLS
-
批准号:2391102
-
项目类别:
-
资助金额:$21.33万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE FUNCTION RELATIONSHIPS IN BRAINSTEM TASTE CELL
-
批准号:6092832
-
项目类别:
-
资助金额:$32.52万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE-FUNCTION RELATIONSHIP OF BRAINSTEM TASTE CELLS
-
批准号:3217786
-
项目类别:
-
资助金额:$14.88万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
STRUCTURE RELATIONSHIPS OF BRAINSTEM TASTE CELLS
-
批准号:2126228
-
项目类别:
-
资助金额:$19.67万
-
财政年份:1992
-
负责人:WILLIAM E RENEHAN
-
依托单位:
PRIMARY AFFERENT PLASTICITY IN THE TRIGEMINAL SYSTEM
-
批准号:3053646
-
项目类别:
-
资助金额:$0.83万
-
财政年份:1985
-
负责人:WILLIAM E RENEHAN
-
依托单位:
MECHANISMS OF TRIGEMINAL PRIMARY AFFERENT ARBOR FORMATION
-
批准号:3753688
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WILLIAM E RENEHAN
-
依托单位:
DEAFFERATION AND TRIGEMINAL AFFERENT PROJECTIONS
-
批准号:3917264
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WILLIAM E RENEHAN
-
依托单位:
DEAFFERATION AND TRIGEMINAL AFFERENT PROJECTIONS
-
批准号:3940154
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WILLIAM E RENEHAN
-
依托单位:
MECHANISMS OF TRIGEMINAL PRIMARY AFFERENT ARBOR FORMATION
-
批准号:3839339
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WILLIAM E RENEHAN
-
依托单位:
DEAFFERATION AND TRIGEMINAL AFFERENT PROJECTIONS
-
批准号:3896842
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:WILLIAM E RENEHAN
-
依托单位: