CHRONIC PROSTATITIS COLLABORATIVE CLINICAL STUDIES

描述（摘自申请人摘要） 慢性非细菌性前列腺炎可能是最常见的诊断， 在美国寻求泌尿科医生护理的男性，但几乎 对这种疾病的病因和治疗方法一无所知 有效地 患有这种疾病的患者有慢性，复发和 以骨盆区疼痛为特征的间歇性状态，刺激性 和排尿障碍症状，以及性功能障碍， 包括射精疼痛 这些症状与 前列腺感染的男性，以及感染性 慢性非细菌性前列腺炎的病因学一直占据着主导地位 关于这种疾病已经很多年了。 然而，大量证据表明， 多年来积累的经验未能令人信服地证明， 感染因子是造成症状的主要原因， 男人与疾病。 被诊断出患有这种疾病的男性通常 长时间接受多个疗程的抗生素治疗 付出了巨大的代价，却几乎没有得到证实的好处。 疾病的进一步定义将取决于三个步骤。 第一、 我们必须能够客观地确定谁患有这种疾病，以及它有多严重， 是基于标准化的标准，包括症状评分和 患者的可测量参数。 第二，我们必须寻找差异 在患有这种疾病的男性和没有这种疾病的正常男性之间， 收集潜在病因学意义的客观信息。 等 研究应包括感染，炎症，免疫， 基因和生化参数，我们将寻找 患病男性和对照组之间的统计学显著差异 男人 最后，针对已确定的致病因素以及 可以设计经验疗法并对其进行客观评价。 我们提出 作为设计的临床中心， 以及在多中心环境中进行此类研究。 我们将展示 我们已经作出并将继续作出重大努力， 对这种疾病有了新的认识，我们有重要的专业知识， 在免疫学和泌尿学研究中，我们有一个记录， 招募患者进入慢性非细菌性 前列腺炎

DESCRIPTION (Taken from the applicant's Abstract) Chronic non-bacterial prostatitis is perhaps the most common diagnosis of men in the United States who seek the care of a urologist, yet almost nothing is known about the etiology of the disease or how to treat it effectively. Patients with this condition have a chronic, relapsing and episodic condition characterized by pain in the pelvic region, irritative and obstructive voiding symptoms, and difficulties with sexual function, including painful ejaculation. These symptoms are indistinguishable from those of men with infection of the prostate gland, and an infectious etiology for chronic non-bacterial prostatitis has dominated the thinking about this disease for many years. However, a large body of evidence accumulated over may years has failed to convincingly demonstrate that any infectious agent is responsible for symptoms in a significant proportion of men with the disease. Men diagnosed with the condition are typically treated with multiple courses of antibiotics for prolonged periods of time at great cost and with little proven benefit. The further definition of the disease will depend upon three steps. First, we must be able to objectively define who has the disease and how severe it is, based upon standardized criteria, including symptom scores and measurable parameters in patients. Second, we must search for differences between men who have the disease and normal men who do not, in order to gather objective information of potential etiologic significance. Such studies should include measures of infectious, inflammatory, immunologic, genetic and biochemical parameters for which we will search for statistically significant differences between men with disease and control men. Finally, therapies directed at identified causative factors as well as empirical therapies can be designed and objectively evaluated. We propose to contribute to this effort by serving as a clinical center for the design and performance of such studies in a multi-center setting. We will show that we have already made and are continuing to make a substantial effort to develop new insights into this disease, that we have significant expertise in immunologic and urologic research, and that we have a track record of patient recruitment into research studies in chronic non-bacterial prostatitis.