IMPLANTABLE NEAR IR GLUCOSE SENSOR

植入式近红外血糖传感器

• 批准号: 2906366
• 负责人: KATHERINE D. CROTHALL
• 金额: $ 17.24万
• 依托单位: ANIMAS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2906366
• 关键词: biomedical equipment development; biosensor device; blood glucose; clinical research; dogs; human subject; hyperglycemia; hypoglycemia; implant; infrared radiation; insulin dependent diabetes mellitus; medical implant science

The goals of the proposal are the development and commercialization of a long-term implantable infrared glucose sensor for insulin dependent diabetics. The sensor will provide quasi-continuous measurement of blood glucose levels and an alarm indicating pending hypo- or hyper- glycemia. The sensor will measure the near infrared absorption spectra across a blood vessel or vascular membrane at a multitude of discrete wavelengths (up to 18 wavelengths) and computing the glucose concentration using the absorption spectra based on an algorithm. The measurement will be taken once every 20 minutes unless specially programmed or when in an alarm situation. In these cases the measurement will be taken every 5 minutes. The initial project is aimed to design and build a breadboard glucose sensor unit and to demonstrate its ability to measure blood glucose in vivo in two dogs for a period of 3 months. Four sensor heads will be implanted in each dog including sensor heads for: vein, arterial, interstitial and vascular membrane. In the next phase of the study, the investigator will design and build the miniaturized implantable long term (5 years) glucose sensor for implantation in human. These sensors will be tested in dogs for one year and in people on acute basis.

该提案的目标是开发和商业化 一种长期植入式胰岛素依赖型红外血糖传感器 糖尿病患者。该传感器将提供准连续的测量 血糖水平和指示即将发生的低血压或高血糖的警报 血糖升高。传感器将测量近红外吸收光谱 在多个离散的血管或血管膜上 波长(最多18个波长)和计算血糖 使用基于算法的吸收光谱进行浓缩。这个 除非有特殊要求，否则每20分钟测量一次 编程或处于警报状态时。在这些情况下， 每隔5分钟进行一次测量。最初的项目旨在 设计和制作面包板葡萄糖传感器单元，并演示 它能够在两只狗体内测量一段时间的血糖 三个月的时间。每只狗体内将植入四个感应头，包括 传感器头：静脉、动脉、间质和血管膜。 在下一阶段的研究中，研究人员将设计和建造 小型化植入式长期(5年)血糖传感器 植入人体内。这些传感器将在狗身上进行测试。 一年中和在人的急性基础上。